6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one

Product Name: 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
CAS No.: 724422-42-8
Chemical Name: 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
Synonyms: 6-bromo-2-methyl-3,4-dihydroisoquinolin-1-one;6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one;1(2H)-ISOQUINOLINONE, 6-BROMO-3,4-DIHYDRO-2-METHYL-;6-bromo-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-one
CBNumber: CB53161882
Molecular Formula: C10H10BrNO
Formula Weight: 240.1
MOL File: 724422-42-8.mol

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6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one Property

storage temp.: Sealed in dry,Room Temperature
Appearance: White to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ark Pharm

Product number: P000053041
Product name: 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
Purity: 97%
Packaging: 100mg
Price: $20
Updated: 2021/12/16

Ark Pharm

Product number: P000053041
Product name: 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
Purity: 97%
Packaging: 250mg
Price: $37
Updated: 2021/12/16

AK Scientific

Product number: 9992DS
Product name: 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
Packaging: 250mg
Price: $126
Updated: 2021/12/16

Ark Pharm

Product number: P000053041
Product name: 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
Purity: 97%
Packaging: 1g
Price: $92
Updated: 2021/12/16

AK Scientific

Product number: 9992DS
Product name: 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
Packaging: 100mg
Price: $104
Updated: 2021/12/16

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6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one Chemical Properties,Usage,Production

Synthesis

147497-32-3

74-88-4

724422-42-8

General procedure for the synthesis of 6-bromo-2-methyl-3,4-dihydro-2H-isoquinolin-1(2H)-one from 6-bromo-3,4-dihydro-2H-isoquinolin-1-one and iodomethane: 6-bromo-3,4-dihydro-2H-isoquinolin-1-one (500 mg, 2.2 mmol) was dissolved in DMF (3 mL) and the solution was cooled down to 0 °C. Under argon protection, 60% NaH (121 mg, 3.0 mmol) was added and the reaction mixture was stirred for 20 min. Subsequently, methyl iodide (0.275 mL, 4.4 mmol) was added and stirring was continued at 0 °C for 1 hour. Upon completion of the reaction, ice water was added to the mixture and the precipitate was collected by filtration. The resulting solid was dried in a vacuum oven at 50 °C for 12 h to afford the target product 6-bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one in 73% yield. Spectral analysis of the product showed m/z 240/242 [M + H]+ with a retention time (rt) of 0.89 min (LC-MS method V012_S01).

References

[1] Patent: WO2014/140075, 2014, A1. Location in patent: Page/Page column 209-210
[2] Patent: US2014/275025, 2014, A1. Location in patent: Paragraph 0537; 0538
[3] Patent: US2016/251376, 2016, A1. Location in patent: Paragraph 0852; 0855; 0856
[4] Patent: US2018/51013, 2018, A1. Location in patent: Paragraph 0597; 0599

6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one Suppliers

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View Lastest Price from 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one manufacturers

Career Henan Chemical Co

Product: 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one 724422-42-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

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