Azido-PEG4- Boc-Hydrazide
- Product Name
- Azido-PEG4- Boc-Hydrazide
- CAS No.
- 1919045-01-4
- Chemical Name
- Azido-PEG4- Boc-Hydrazide
- Synonyms
- Azido-PEG4-hydrazide-Boc;Azido-PEG4- Boc-Hydrazide;Azido-PEG4-t-Boc-Hydrazide;N'-Boc-1-azido-3,6,9,12-tetraoxapentadecane-15-hydrazide;tert-Butyl 18-azido-4-oxo-7,10,13,16-tetraoxa-2,3-diazaoctadecanoate
- CBNumber
- CB53162874
- Molecular Formula
- C16H31N5O7
- Formula Weight
- 405.44664
- MOL File
- 1919045-01-4.mol
Azido-PEG4- Boc-Hydrazide Property
- storage temp.
- Storage temp. 2-8°C
- form
- Viscous Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- BP-23197
- Product name
- Azido-PEG4-t-Boc-hydrazide
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- BP-23197
- Product name
- Azido-PEG4-t-Boc-hydrazide
- Purity
- 98%
- Packaging
- 500mg
- Price
- $720
- Updated
- 2021/12/16
Azido-PEG4- Boc-Hydrazide Chemical Properties,Usage,Production
Description
Azido-PEG4-t-Boc-hydrazide is a Boc-protected PEG linker containing an azide group (N3). The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc site can be deprotected under mild acidic conditions to form a reactive hydrazide, which can then be coupled with various carbonyl groups.
Uses
Azido-PEG4-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-hydrazide-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG4- Boc-Hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
Azido-PEG4- Boc-Hydrazide Suppliers
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View Lastest Price from Azido-PEG4- Boc-Hydrazide manufacturers
- Product
- Azido-PEG4-hydrazide-Boc 1919045-01-4
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23