2-(4-fluorophenyl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid
- Product Name
- 2-(4-fluorophenyl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid
- CAS No.
- 1268863-35-9
- Chemical Name
- 2-(4-fluorophenyl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid
- Synonyms
- BioE1115;BIOE-1115;BioE-1115 ，S0995;BioE-1115, 10 mM in DMSO;PAS Kinase Inhibitor, BioE-1115;2-(4-fluorophenyl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid;6-Quinoxalinecarboxylic acid, 2-(4-fluorophenyl)-3-[methyl(1-methylethyl)amino]-;BioE 1115,Threonine proteases,Ser/Thr Protease,Inhibitor,BioE1115,inhibit,Serine proteases,Serine endopeptidases,BioE-1115,Casein Kinase
- CBNumber
- CB53166382
- Molecular Formula
- C19H18FN3O2
- Formula Weight
- 339.3635232
- MOL File
- 1268863-35-9.mol
2-(4-fluorophenyl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid Property
- storage temp.
- 2-8°C
- solubility
- DMSO: 50mg/mL
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5.32306
- Product name
- PAS Kinase Inhibitor, BioE-1115
- Packaging
- 10 mg
- Price
- $227
- Updated
- 2025/07/31
- Product number
- CS-0106727
- Product name
- BioE-1115
- Purity
- 98.08%
- Packaging
- 10mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-0106727
- Product name
- BioE-1115
- Purity
- 98.08%
- Packaging
- 50mg
- Price
- $710
- Updated
- 2021/12/16
- Product number
- CS-0106727
- Product name
- BioE-1115
- Purity
- 98.08%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 020421
- Product name
- BioE-1115
- Packaging
- 003
- Price
- $1900
- Updated
- 2021/12/16
2-(4-fluorophenyl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid Chemical Properties,Usage,Production
Uses
BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. BioE-1115 is also a potent casein kinase 2α inhibitor with an IC50 of ~10 μM[1].
Biological Activity
Cell permeable: yes', 'Primary Target
PASK
in vivo
BioE-1115 (1-100 mg/kg; oral gavage; daily; for 7 days; male Sprague-Dawley rats) treatment shows a dose-dependent suppression of the expression of Gpat1, Fasn and all other SREBP-1c target genes analyzed. SREBP-1 maturation in liver is also suppressed in BioE-1115 treated rats at 10, 30 and 100 mg/kg doses. A calculated measure of insulin resistance, HOMA-IR, is decreased in a dose-dependent manner by BioE-1115 administration. Hepatic and serum TAG are decreased in a dose-dependent manner by BioE-1115 administration. BioE-1115 treatment causes a significant decrease in serum glucose. Both SREBP-1c and SREBP-1a mRNA are modestly decreased at the highest doses. Neither dose of BioE-1115 causes a significant change in either liver weight or body weight[1].
| Animal Model: | Male Sprague-Dawley rats (12 weeks of age; 129.4 ± 0.63 g) fed with high fructose diet[1] |
| Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg and 100 mg/kg |
| Administration: | Oral gavage; daily; for 7 days |
| Result: | Treated with 10, 30 and 100 mg/kg, showed a dose-dependent suppression of the expression of Gpat1, Fasn and all other SREBP-1c target genes analyzed. Decreased hepatic expression of lipogenic SREBP-1c target genes, decreased serum triglycerides and partially reversed insulin resistance. |
IC 50
CK2α: 10 μM (IC50)
References
[1] Wu X, et al. PAS kinase drives lipogenesis through SREBP-1 maturation. Cell Rep. 2014 Jul 10;8(1):242-55. DOI:10.1016/j.celrep.2014.06.006
2-(4-fluorophenyl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid Preparation Products And Raw materials
Raw materials
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