LDC4297
- Product Name
- LDC4297
- CAS No.
- 1453834-21-3
- Chemical Name
- LDC4297
- Synonyms
- LDC4297;CS-2540;CS-2539;LDC044297;LDC4297;LDC 4297;LDC4297(LDC044297);N-(2-(1H-Pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-yloxy)pyrazolo[1,5-a][1,3,5]triazin-4-amine;Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-(1-methylethyl)-2-(3-piperidinyloxy)-N-[[2-(1H-pyrazol-1-yl)phenyl]methyl]-
- CBNumber
- CB53171481
- Molecular Formula
- C23H28N8O
- Formula Weight
- 432.52
- MOL File
- 1453834-21-3.mol
LDC4297 Property
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF:20.0(Max Conc. mg/mL);46.24(Max Conc. mM)
DMSO:40.0(Max Conc. mg/mL);92.48(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);46.24(Max Conc. mM) - form
- A crystalline solid
- pka
- 8.69±0.10(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 23398
- Product name
- LDC-4297
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 23398
- Product name
- LDC-4297
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 23398
- Product name
- LDC-4297
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- 23398
- Product name
- LDC-4297
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $573
- Updated
- 2024/03/01
- Product number
- L367665
- Product name
- LDC4297
- Packaging
- 25mg
- Price
- $3795
- Updated
- 2021/12/16
LDC4297 Chemical Properties,Usage,Production
Description
LDC-4297 is an inhibitor of cyclin-dependent kinase 7 (CDK7; IC50 = <5 nM). It is selective for CDK7 over CDK4, CDK6, and CDK9 (IC50s = >10, >10, and 1.71 μM), however, it also inhibits CDK2 and CDK1 (IC50s = 6.4 and 53.7 nM, respectively). LDC-4297 (10-100 nM) induces apoptosis in A549, HeLa, and HCT116 cancer cells in a concentration-dependent manner. It inhibits human cytomegalovirus (HCMV) replication in human fibroblasts (EC50 = 24.5 nM). LDC-4297 also reduces replication of Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae family viruses (EC50s = 0.02-1.13 μM).
Uses
Cyclin-dependent protein kinase 7 (CDK7) is involved with a broad range of regulatory roles in cell cycle and transcription, which is essential for viral replication. LDC 4297 is a CDK7 inhibitor that can be used to develop antiviral drugs.
Definition
ChEBI: LDC4297 is a pyrazolotriazine that is pyrazolo[1,5-a][1,3,5]triazine substituted by a piperidin-3-yloxy group, [2-(1H-pyrazol-1-yl)benzyl]nitrilo group and an isopropyl group at positions 2, 4 and 8 respectively. It is a potent and selective CDK7 inhibitor and exhibits antiviral activity. It has a role as an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an apoptosis inducer, an antineoplastic agent and an antiviral agent. It is a pyrazolotriazine, a member of pyrazoles, a member of piperidines, a secondary amino compound and an aromatic ether.