ChemicalBook > CAS DataBase List > Pan-RAS-IN-1
Pan-RAS-IN-1
- Product Name
- Pan-RAS-IN-1
- CAS No.
- 1835283-94-7
- Chemical Name
- Pan-RAS-IN-1
- Synonyms
- Ras-IN-3144;Pan-RAS-IN-1;Pan-RAS inhibitor 1;pan-Ras inhibitor 3144;Ras-IN-3144，Pan-RAS-IN-1;Pan-RAS-IN-1, 10 mM in DMSO;pan-Ras inhibitor 3144 (Compound 3144);PanRASIN1,inhibit,Ras,Pan RAS IN 1,Inhibitor;4-Piperidinecarboxamide, 4-amino-N-[3-[5-[[4-[(2,6-dichlorophenyl)methyl]-1-piperazinyl]methyl]-3-[4-(trifluoromethoxy)phenyl]-1H-indol-1-yl]propyl]-
- CBNumber
- CB53171698
- Molecular Formula
- C36H41Cl2F3N6O2
- Formula Weight
- 717.65
- MOL File
- 1835283-94-7.mol
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Pan-RAS-IN-1 Property
- Boiling point:
- 809.7±65.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 50 mg/mL (69.67 mM)
- form
- Solid
- pka
- 17.09±0.20(Predicted)
- color
- White to yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-6466
- Product name
- Pan-RAS-IN-1
- Purity
- 99.87%
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6466
- Product name
- Pan-RAS-IN-1
- Purity
- 99.87%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6466
- Product name
- Pan-RAS-IN-1
- Purity
- 99.87%
- Packaging
- 10mg
- Price
- $720
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6466
- Product name
- Pan-RAS-IN-1
- Purity
- 99.87%
- Packaging
- 25mg
- Price
- $1440
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6466
- Product name
- Pan-RAS-IN-1
- Purity
- 99.87%
- Packaging
- 50mg
- Price
- $2340
- Updated
- 2021/12/16
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Pan-RAS-IN-1 Chemical Properties,Usage,Production
Uses
Pan-RAS-IN-1 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors.
in vivo
Pan-RAS-IN-1 administration results in inhibition of tumor growth over 15 days of treatment. Pan-RAS-IN-1-treated mice exhibits decreased tumor pERK levels compared with vehicle treated mice. A modest increase in cleaved caspase-3 is also observed, showing that in this model, pan-RAS-IN-1 has the capacity to induce caspase activation[1].
References
[1] Welsch ME, et al. Multivalent Small-Molecule Pan-RAS Inhibitors. Cell. 2017 Feb 23;168(5):878-889.e29. DOI:10.1016/j.cell.2017.02.006
Pan-RAS-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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Pan-RAS-IN-1 Suppliers
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
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- China
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