TRC051384
- Product Name
- TRC051384
- CAS No.
- 867164-40-7
- Chemical Name
- TRC051384
- Synonyms
- TRC051384;TRC 051384; TRC-051384;HSP,TRC-051384,TRC051384,Heat shock proteins,Inhibitor,inhibit;1-(2-Morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea;N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea;Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-
- CBNumber
- CB53171704
- Molecular Formula
- C25H31N5O4
- Formula Weight
- 465.54
- MOL File
- 867164-40-7.mol
TRC051384 Property
- Boiling point:
- 685.7±55.0 °C(Predicted)
- Density
- 1.260±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥109 mg/mL in DMSO
- form
- solid
- pka
- 13.47±0.46(Predicted)
- color
- Yellow
N-Bromosuccinimide Price
- Product number
- 4734
- Product name
- TRC051384
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $273
- Updated
- 2021/12/16
- Product number
- 256966
- Product name
- TRC 051384
- Packaging
- 10mg
- Price
- $545
- Updated
- 2021/12/16
- Product number
- T895540
- Product name
- TRC051384
- Packaging
- 10mg
- Price
- $255
- Updated
- 2021/12/16
- Product number
- CS-6513
- Product name
- TRC051384
- Purity
- 98.19%
- Packaging
- 200mg
- Price
- $2400
- Updated
- 2021/12/16
- Product number
- CS-6513
- Product name
- TRC051384
- Purity
- 98.19%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
TRC051384 Chemical Properties,Usage,Production
Uses
N-[2-(4-Morpholinyl)ethyl]-N''-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea is a key reactant in the synthesis of TRC051384, which is a small molecule HSP70 inducer.
Biological Activity
trc 051384, belonging to substituted 2-propen-1-one class, is a potent inducer of heat shock protein 70 (hsp70) [1]. induction of hsp70 is a natural response of stressed cells that protects neuronal cells from a variety of insults including acute ischemia. therefore, induction of hsp70 provides a potential target for the treatment of stroke [1].
in vitro
induction of hsp70 by trc 051384 (6.25, and 12.5 μm) involved heat shock factor-1 (hsf1) activation in hela cells and led to increasing chaperone and anti-inflammatory activity [1]. moreover, trc 051384 (10-50 μm) dose-dependently induced hspa1b overexpression in endothelial cells as well as leucocyte origin [2].
in vivo
trc 051384 (9 mg/kg, intra-peritoneal administration) treatment significantly decreased stroke-associated neuronal injury, disability, and increased survival in a rat model of transient ischemic stroke [1]. in addition, trc 051384 (9 mg/kg, intra-peritoneal administration) delayed thrombus formation without increasing bleeding risk in wt mice [2].
target
hsp70
References
1. mohanan a, deshpande s, jamadarkhana pg, kumar p, gupta rc, chauthaiwale v, et al. delayed intervention in experimental stroke with trc 051384--a small molecule hsp70 inducer. neuropharmacology. 2011;60(6):991-9. 2. allende m, molina e, guruceaga e, tamayo i, gonzalez-porras jr, gonzalez-lopez tj, et al. hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk. cardiovasc res. 2016;110(3):309-18.