N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide

Product Name: N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide
CAS No.: 325457-89-4
Chemical Name: N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide
Synonyms: ICA-027243;ICA-27243, 10 mM in DMSO;N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide;Benzamide, N-(6-chloro-3-pyridinyl)-3,4-difluoro-;antiepileptic,hyperpolarization,ICA-27243,opener,Inhibitor,KcsA,Potassium Channel,inhibit,KCNQ3,KCNQ2,ICA 27243,anticonvulsant,ICA27243
CBNumber: CB53172514
Molecular Formula: C12H7ClF2N2O
Formula Weight: 268.65
MOL File: 325457-89-4.mol

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N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide Property

Boiling point:: 318.5±42.0 °C(Predicted)
Density: 1.476±0.06 g/cm3(Predicted)
solubility: DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml
form: Solid
pka: 10.40±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 40827
Product name: ICA 27243
Purity: ≥98%
Packaging: 5mg
Price: $107
Updated: 2026/04/30

Cayman Chemical

Product number: 40827
Product name: ICA 27243
Purity: ≥98%
Packaging: 10mg
Price: $203
Updated: 2026/04/30

Cayman Chemical

Product number: 40827
Product name: ICA 27243
Purity: ≥98%
Packaging: 50mg
Price: $854
Updated: 2026/04/30

Cayman Chemical

Product number: 40827
Product name: ICA 27243
Purity: ≥98%
Packaging: 100mg
Price: $1494
Updated: 2026/04/30

Matrix Scientific

Product number: 178889
Product name: N-(6-Chloropyridin-3-yl)-3,4-difluorobenzamide
Purity: 95%
Packaging: 2.500g
Price: $1320
Updated: 2021/12/16

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N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide Chemical Properties,Usage,Production

Uses

ICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC50 of 0.38 μM. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and anticonvulsant effects[1][2].

in vivo

ICA-27243 (1-100 mg/kg; oral administration; male CD-1 mice) has anticonvulsant activity (ED₅₀ of 8.4 mg/kg) in the mouse maximal electroshock epilepsy model^[1].

Animal Model:	Male CD-1 mice with electroshock assay^[1]
Dosage:	1-100 mg/kg
Administration:	Oral administration
Result:	Produced a dose-dependent increase in the latency to hind limb extension, exhibiting an ED₅₀ value of 8.4 mg/kg.

References

[1] Wickenden AD, et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86. DOI:10.1124/mol.107.043216
[2] Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4. DOI:10.1021/ml200053x
[3] JOHN P. REDROBE Alexander N N. Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania[J]. Behavioural Brain Research, 2009, 198 2: Pages 481-485. DOI: 10.1016/j.bbr.2008.12.027

N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide Suppliers

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325457-89-4, N-(6-Chloropyridin-3-Yl)-3,4-DifluorobenzamideRelated Search:

N-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide

ICA-027243

Benzamide, N-(6-chloro-3-pyridinyl)-3,4-difluoro-

antiepileptic,hyperpolarization,ICA-27243,opener,Inhibitor,KcsA,Potassium Channel,inhibit,KCNQ3,KCNQ2,ICA 27243,anticonvulsant,ICA27243

ICA-27243, 10 mM in DMSO

325457-89-4