4-FLUOROCINNAMALDEHYDE
- Product Name
- 4-FLUOROCINNAMALDEHYDE
- CAS No.
- 51791-26-5
- Chemical Name
- 4-FLUOROCINNAMALDEHYDE
- Synonyms
- CHEMBRDG-BB 4004292;Fluorocinnamaldehyde;trans-4-FluorocinnaMaldehyde;(E)-3-(4-Fluorophenyl)-2-propenal;TRANS-4-FLUOROCINNAMALDEHYDE, 97%;trans-4-Fluorocinnamaldehyde;2-PROPENAL, 3-(4-FLUOROPHENYL)-,(2E)
- CBNumber
- CB5320048
- Molecular Formula
- C9H7FO
- Formula Weight
- 150.15
- MOL File
- 51791-26-5.mol
4-FLUOROCINNAMALDEHYDE Property
- Boiling point:
- 245.6±15.0 °C(Predicted)
- Density
- 1.146 g/mL at 25 °C
- refractive index
- n20/D 1.599
- Flash point:
- >110°C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- liquid
N-Bromosuccinimide Price
- Product number
- 683027
- Product name
- trans-4-Fluorocinnamaldehyde
- Purity
- 95%
- Packaging
- 500mg
- Price
- $154
- Updated
- 2025/07/31
- Product number
- F588633
- Product name
- trans-4-Fluorocinnamaldehyde
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 0552AQ
- Product name
- trans-4-Fluorocinnamaldehyde
- Packaging
- 500mg
- Price
- $236
- Updated
- 2021/12/16
- Product number
- 51791265
- Product name
- (E)-3-(4-Fluorophenyl)acrylaldehyde
- Packaging
- 500g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- CD00003689
- Product name
- (E)-3-(4-Fluorophenyl)acrylaldehyde
- Purity
- 97%
- Packaging
- 1000g
- Price
- $440
- Updated
- 2021/12/16
4-FLUOROCINNAMALDEHYDE Chemical Properties,Usage,Production
Uses
trans-4-Fluorocinnamaldehyde is a reagent used in the preparation of novel terminal bipheny-based diapophytoene desaturases which are used in the treatment of Staphylococcus aureus infections.
Synthesis
459-57-4
2136-75-6
51791-26-5
GENERAL STEPS: 4-Fluorobenzaldehyde (9.40 g, 75.8 mmol) and formylmethylenetriphenylphosphorane (30.0 g, 98.6 mmol) were suspended in toluene (150 mL), and the reaction was stirred for 12 hours at 70 °C. After completion of the reaction, the reaction mixture was treated with ethyl acetate (EtOAc) and water (H2O). The organic layer was separated, washed with saturated saline (brine), dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. The residue was purified by column chromatography to afford unsaturated aldehyde (8.04 g, 71% yield). The resulting aldehyde (8.04 g, 53.5 mmol) was dissolved in a solvent mixture of pyridine (100 mL) and dichloromethane (50 mL) at 0 °C and iodine monochloride (17.4 g, 107 mmol) was added. After stirring at 0 °C for 5 h, the reaction was quenched with aqueous sodium thiosulfate (Na2S2O3) and treated with ethyl acetate (EtOAc). The organic layer was separated, washed with saturated saline (brine), dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. The residue was purified by column chromatography to afford p-fluorocinnamaldehyde (10.01 g, 68% yield).1H-NMR (300 MHz, DMSO-d6) δ: 7.43 (2H, t, J = 8.5 Hz), 8.13 (2H, dd, J = 8.5, 5.5 Hz), 8.54 (1H, s), 8.84 (1H, s).
References
[1] Patent: WO2007/77961, 2007, A2. Location in patent: Page/Page column 302-303
[2] Angewandte Chemie - International Edition, 2011, vol. 50, # 8, p. 1910 - 1913
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 3, p. 719 - 725
4-FLUOROCINNAMALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
4-FLUOROCINNAMALDEHYDE Suppliers
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View Lastest Price from 4-FLUOROCINNAMALDEHYDE manufacturers
- Product
- trans-4-FluorocinnaMaldehyde 51791-26-5
- Price
- US $0.00-0.00/Kg
- Min. Order
- 100G
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-17