9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
- Product Name
- 9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
- CAS No.
- 4551-00-2
- Chemical Name
- 9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
- Synonyms
- NSC-70220;SOS1 inhibitor 1;NSC 70220,NSC70220;9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
- CBNumber
- CB53221344
- Molecular Formula
- C22H15NO2
- Formula Weight
- 325.36
- MOL File
- 4551-00-2.mol
9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]- Property
- Melting point:
- 186 °C
- Boiling point:
- 569.6±49.0 °C(Predicted)
- Density
- 1.321±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C,unstable in solution, ready to use.
- solubility
- DMSO: 12.5 mg/mL (38.42 mM)
- form
- Solid
- color
- Light yellow to yellow
9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]- Chemical Properties,Usage,Production
Biological Activity
NSC-70220 is a selective allosteric SOS1 inhibitor. It has an anticancer effects and inhibits allosteric site activation and partially inhibits catalytic site activation.
in vitro
The growth inhibitory rate (IR)=(average OD value in the control group-average OD value in the treatment group)/average OD value in the control group×100% are compared. Treatments with NSC-70220 at 40 μM and NSC-658497 at 30 μM result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of NSC-70220 and NSC-658497 on cell growth It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of NSC-70220 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of NSC-70220 overnight resulted in lower expression levels of P-ERK.
target
SOS1.
9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]- Preparation Products And Raw materials
Raw materials
Preparation Products
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