5-CHLORO-3-IODO-1H-INDAZOLE

Product Name: 5-CHLORO-3-IODO-1H-INDAZOLE
CAS No.: 351456-45-6
Chemical Name: 5-CHLORO-3-IODO-1H-INDAZOLE
Synonyms: 351456-46-5;5-CHLORO-3-IODOINDAZOLE;5-chloro-3-iodo-2H-indazole;5-CHLORO-3-IODO-1H-INDAZOLE;1H-Indazole, 5-chloro-3-iodo-
CBNumber: CB5322673
Molecular Formula: C7H4ClIN2
Formula Weight: 278.48
MOL File: 351456-45-6.mol

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5-CHLORO-3-IODO-1H-INDAZOLE Property

Boiling point:: 391.5±22.0 °C(Predicted)
Density: 2.156±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 10.85±0.40(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: OR60117
Product name: 5-Chloro-3-iodo-1H-indazole
Packaging: 1g
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC51611
Product name: 5-Chloro-3-iodo-1H-indazole
Packaging: 250mg
Price: $87.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC51611
Product name: 5-Chloro-3-iodo-1H-indazole
Packaging: 500mg
Price: $140
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0013556
Product name: 5-CHLORO-3-IODO-1H-INDAZOLE
Purity: 95.00%
Packaging: 250MG
Price: $220.5
Updated: 2021/12/16

Apolloscientific

Product number: OR60117
Product name: 5-Chloro-3-iodo-1H-indazole
Packaging: 500mg
Price: $38
Updated: 2021/12/16

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5-CHLORO-3-IODO-1H-INDAZOLE Chemical Properties,Usage,Production

Synthesis

698-26-0

351456-45-6

General procedure for the synthesis of 3-iodo-5-chloroindazole from 5-chloro-1H-indazole: the direct iodination reaction was carried out by referring to the method previously reported by Bocchi [28] with slight modifications. The procedure was as follows: 5-chloro-1H-indazole (3 g, 25.4 mmol), iodine (12.7 g, 50.03 mmol) and potassium hydroxide (5.34 g, 95.25 mmol) were dissolved in DMF (7 mL) and the reaction was stirred for 3 h at room temperature. Upon completion of the reaction, the reaction was quenched with saturated sodium bisulfite solution (150 mL), at which time a precipitate was generated. The precipitate was collected by vacuum filtration and washed with water three times (30 mL each). The resulting solid was dried in a vacuum oven at 30 °C overnight to give 6.17 g of the light yellow solid product 3-iodo-5-chloroindazole. Yield: 100%; Melting point: 136-138 °C (literature value:[36] 134-136 °C); IR (KBr) ν (cm^-1): 3086 (NH); 424 (C-I). 1H-NMR δ (ppm): 13.50 (1H, s, H-1); 7.55 (1H, d, J=8.6 Hz, H-7); 7.45- 7.40 (2H, m, H-6 and H-4); 7.19 (1H, dd, J=7.5Hz, H-5).13C-NMR δ (ppm): 140.41; 127.22; 126.79; 121.23; 120.39; 110.51; 93.49. HRMS calculated value C7H4ClIN2: 277.9107 , measured value: 277.9109.

References

[1] Molecules, 2018, vol. 23, # 8,
[2] Patent: WO2017/98328, 2017, A2. Location in patent: Paragraph 00208
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 9, p. 2793 - 2800

5-CHLORO-3-IODO-1H-INDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CHLORO-3-IODO-1H-INDAZOLE Suppliers

China 89 Germany 1 India 1 United Kingdom 3 United States 20 Global 114

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View Lastest Price from 5-CHLORO-3-IODO-1H-INDAZOLE manufacturers

Career Henan Chemical Co

Product: 5-CHLORO-3-IODO-1H-INDAZOLE 351456-45-6
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-13

351456-45-6, 5-CHLORO-3-IODO-1H-INDAZOLERelated Search:

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5-CHLORO-3-IODO-1H-INDAZOLE

5-CHLORO-3-IODOINDAZOLE

1H-Indazole, 5-chloro-3-iodo-

351456-46-5

5-chloro-3-iodo-2H-indazole

351456-45-6

351456-46-5

C7H4ClIN3