CARIPORIDE

ChemicalBook > CAS DataBase List > CARIPORIDE

Product Name: CARIPORIDE
CAS No.: 159138-80-4
Chemical Name: CARIPORIDE
Synonyms: CS-1692;CARIPORIDE;Cariporide (HOE-642);N-(diaminomethylene)-4-isopropyl-3-mesyl-benzamide;N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide;N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide;BenzaMide,N-(aMinoiMinoMethyl)-4-(1-Methylethyl)-3-(Methylsulfonyl)-;Sodium/hydrogen Exchanger,Na+/H+ Exchanger (NHE),inhibit,Sodium-hydrogen Exchanger,HOE642,Inhibitor,Cariporide,HOE 642
CBNumber: CB5324031
Molecular Formula: C12H17N3O3S
Formula Weight: 283.35
MOL File: 159138-80-4.mol

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CARIPORIDE Property

Melting point:: 90-94° (dec)
Density: 1.34
storage temp.: 2-8°C
solubility: insoluble in H2O; ≥12.05 mg/mL in DMSO; ≥2.675 mg/mL in EtOH with gentle warming and ultrasonic
form: powder
color: white to beige

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Safety

RTECS: CV2310560

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1360
Product name: Cariporide
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $85.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1360
Product name: Cariporide
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $205.2
Updated: 2024/03/01

Cayman Chemical

Product number: 16935
Product name: Cariporide
Purity: ≥95%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 16935
Product name: Cariporide
Purity: ≥95%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 16935
Product name: Cariporide
Purity: ≥95%
Packaging: 50mg
Price: $477
Updated: 2024/03/01

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CARIPORIDE Chemical Properties,Usage,Production

Uses

Reduction of death and nonfatal myocardial infarction in patients undergoing CABG surgery.

Uses

Cariporide is an Na+/H+ exchange inhibitor that functions to improve cellular integrity following events of cardiac ischemia and reperfusion (most commonly seen in non-heart beating donor organs). Cariporide is also used to prevent heart attacks in high-risk ischemic patients.

Biological Activity

na–h exchange (nhe) represents an important mechanism for mediating such injury. nhe represents an important mechanism for the development of myocardial ischemic and reperfusion injury and inhibitors have been consistently shown to protect the ischemic and reperfused heart by correcting the ionic imbalance associated with this form of pathological insult. cariporide is a potent nhe inhibitor.

Biochem/physiol Actions

Cariporide is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. Cariporide has shown cardioprotective and antiarrhythmic effects, and has recently been investigated for anticancer activity.

in vitro

cariporide concentration dependently inhibited the amiloride sensitive sodium influx in rabbit erythrocytes, reduced the swelling of human platelets caused by intracellular acidification, and delayed ph recovery in rat cardiomyocytes [1].

in vivo

in anaesthetised rats undergoing coronary artery ligation intravenous and oral pretreatment with cariporide caused a dose dependent reduction or a complete prevention of ventricular premature beats, ventricular fibrillation, and ventricular tachycardia. the compound was well tolerated and neutral to circulatory variables [1].

IC 50

0.05, 3 and 1000 μm for nhe1, nhe3 and nhe2, respectively

storage

Store at +4°C

CARIPORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CARIPORIDE manufacturers

Career Henan Chemical Co

Product: CARIPORIDE 159138-80-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

159138-80-4, CARIPORIDERelated Search:

HOE 642 cariporide mesilate 3-(Methylsulfonyl)benzaldehyde CARIPORIDE CHEMBRDG-BB 4002912

CARIPORIDE

N-(diaminomethylene)-4-isopropyl-3-mesyl-benzamide

N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide

N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide

BenzaMide,N-(aMinoiMinoMethyl)-4-(1-Methylethyl)-3-(Methylsulfonyl)-

Cariporide (HOE-642)

CS-1692

Sodium/hydrogen Exchanger,Na+/H+ Exchanger (NHE),inhibit,Sodium-hydrogen Exchanger,HOE642,Inhibitor,Cariporide,HOE 642

159138-80-4

159138-80-3

C12H17N3O3S

Inhibitors