BETA-POMPILIDOTOXIN

Product Name: BETA-POMPILIDOTOXIN
CAS No.: 216064-36-7
Chemical Name: BETA-POMPILIDOTOXIN
Synonyms: β-PMTX;BETA-PMTX;β-Pompilidotoxin;β-Pompilidotoxin;b-Pompilidotoxin;RIKIGLFDQLSRL-NH2;BETA-POMPILIDOTOXIN;L-Leucinamide, L-arginyl-L-isoleucyl-L-lysyl-L-isoleucylglycyl-L-leucyl-L-phenylalanyl-L-α-aspartyl-L-glutaminyl-L-leucyl-L-seryl-L-arginyl-
CBNumber: CB5324309
Molecular Formula: C71H124N22O17
Formula Weight: 1557.88
MOL File: 216064-36-7.mol

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BETA-POMPILIDOTOXIN Property

storage temp.: −20°C
solubility: ≥155.8 mg/mL in DMSO; insoluble in EtOH; ≥22.05 mg/mL in H2O
form: solid
color: White to off-white
Water Solubility: Soluble to 1 mg/ml in water

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1539
Product name: beta-Pompilidotoxin
Packaging: 1
Price: $228
Updated: 2021/12/16

ApexBio Technology

Product number: A1132
Product name: β-Pompilidotoxin
Packaging: 1mg
Price: $40
Updated: 2021/12/16

ApexBio Technology

Product number: A1132
Product name: β-Pompilidotoxin
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ApexBio Technology

Product number: A1132
Product name: β-Pompilidotoxin
Packaging: 10mg
Price: $200
Updated: 2021/12/16

ApexBio Technology

Product number: A1132
Product name: β-Pompilidotoxin
Packaging: 25mg
Price: $280
Updated: 2021/12/16

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BETA-POMPILIDOTOXIN Chemical Properties,Usage,Production

Biological Activity

β-pompilidotoxin, (c71h124n22o17), a peptide with the sequence h2n-arg-ile-lys-ile-gly-leu-phe-asp-gln-leu-ser-arg-leu-amide, mw= 1557.88. pompilidotoxin is a toxin from the venom of spider wasps that slows the inactivation of na+channels. α-pompilidotoxin (α-pmtx) can be extracted from the venom of a solitary wasp, anopolis samariensis. β-pompilidotoxin (β-pmtx) originates from the venom of another wasp, batozonellus maculifrons(1). homology α-pmtx has no structural homology with other toxins. it lacks disulfide bonds which are known to be present in other toxins acting on sodium channels, such as sea anemone toxins or scorpion toxins(2). both α- and β-pmtx slow the inactivation of neuronal sodium channels (but not heart sodium channels), possibly by binding to the neurotoxin receptor site 3 on the extracellular surface of the sodium channel(3). β-pmtx has higher potency than α-pmtx. by slowing down the inactivation of sodium channels, pmtxs can potentiate synaptic transmission in the lobster neuromuscular endplate.figure1 formula of β-pompilidotoxin

References

1. Konno K, Hisada M, Itagaki Y, Naoki H, Kawai N, Miwa A, Yasuhara T, Takayama H (1998). "Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms". Biochem Biophys Res Commun. 250 (3): 612–6.2. Sahara Y, Gotoh M, Konno K, Miwa A, Tsubokawa H, Robinson HP, Kawai N (2000). "A new class of neurotoxin from wasp venom slows inactivation of sodium current". Eur J Neurosci. 12 (6): 1961–70.3. Kawai N, Konno K (2004). "Molecular determinants of two neurotoxins that regulate sodium current inactivation in rat hippocampal neurons". Neurosci Lett. 361 (1-3): 44–6.

BETA-POMPILIDOTOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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BETA-POMPILIDOTOXIN Suppliers

China 22 Germany 1 Switzerland 1 United Kingdom 1 United States 7 Global 32

3B Pharmachem (Wuhan) International Co.,Ltd.

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Hangzhou Sinoda Pharmaceutical Technology Co. LTD

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Shanghai HongTide Biotechnology Co.,Ltd.

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216064-36-7, BETA-POMPILIDOTOXINRelated Search:

BETA-POMPILIDOTOXIN

BETA-PMTX

BETA-POMPILIDOTOXIN

RIKIGLFDQLSRL-NH2

b-Pompilidotoxin

β-PMTX

β-Pompilidotoxin

L-Leucinamide, L-arginyl-L-isoleucyl-L-lysyl-L-isoleucylglycyl-L-leucyl-L-phenylalanyl-L-α-aspartyl-L-glutaminyl-L-leucyl-L-seryl-L-arginyl-

β-Pompilidotoxin

216064-36-7

C71H124N22O17

Sodium Channel Modulators

Voltage-gated Ion Channels

Other Sodium Channel Modulators

Ion Channels

Monovalent Ion Channels

Cell Signaling and Neuroscience

Cell Biology

BioChemical