AM-2099
- Product Name
- AM-2099
- CAS No.
- 1443373-17-8
- Chemical Name
- AM-2099
- Synonyms
- AM-2099;AM 2099;AM-2099;4-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-2-thiazolyl-7-quinazolinesulfonamide;7-Quinazolinesulfonamide, 4-[2-methoxy-4-(trifluoromethyl)phenyl]-N-2-thiazolyl-;4-(2-methoxy-4-(trifluoromethyl)phenyl)-N-(thiazol-2-yl)quinazoline-7-sulfonamide
- CBNumber
- CB53309530
- Molecular Formula
- C19H13F3N4O3S2
- Formula Weight
- 466.46
- MOL File
- 1443373-17-8.mol
AM-2099 Property
- Boiling point:
- 572.1±60.0 °C(Predicted)
- Density
- 1.531±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 150 mg/mL (321.57 mM)
- form
- Solid
- pka
- 6.11±0.50(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-6894
- Product name
- AM-2099
- Purity
- 98.02%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-6894
- Product name
- AM-2099
- Purity
- 98.02%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-6894
- Product name
- AM-2099
- Purity
- 98.02%
- Packaging
- 50mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- CS-6894
- Product name
- AM-2099
- Purity
- 98.02%
- Packaging
- 100mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- DC9909
- Product name
- AM2099
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1200
- Updated
- 2021/12/16
AM-2099 Chemical Properties,Usage,Production
Description
AM-2099 is a potent and selective NaV1.7 Inhibitor (hNav1.7 IC50 = 0.16 uM; hNav1.5 IC50 > 30 uM; Papp = 31 x 10 (-6)cm/s; Rat IV CL (b/h/kg) \= 0.54; cLogD = 2.1). AM-2099 demonstrated a favorable pharmacokinetic profile in rat and dog and demonstrated dose-dependent reduction of histamine-induced scratching bouts in a mouse behavioral model following oral dosing.
Uses
AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 with an IC50 of 0.16 μM for human Nav1.7.
in vivo
AM-2099 demonstrates a favorable pharmacokinetic profile in rat and dog. In rats AM-2099 shows low total clearance and moderate Vdss and half-life. In contrast, when dosed in dogs AM-2099 shows very low clearance, a low Vdss and long halflife (18 h). AM-2099 demonstrates a dose-dependent increase in plasma exposure with a concomitant dose-dependent reduction in scratching bouts compared to vehicle-treated animals, with a statistically significant reduction observed at the 60 mg/kg dose[1].
IC 50
Nav1.7
References
[1] Marx IE, et al. Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement. ACS Med Chem Lett. 2016 Sep 21;7(12):1062-1067. DOI:10.1021/acsmedchemlett.6b00243
AM-2099 Preparation Products And Raw materials
Raw materials
Preparation Products
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