PBI-4050 Sodium salt

Product Name: PBI-4050 Sodium salt
CAS No.: 1254472-97-3
Chemical Name: PBI-4050 Sodium salt
Synonyms: Fezagepras (sodium);PBI-4050 Sodium salt;Setogepram sodium salt;Fezagepras sodium, 10 mM in DMSO
CBNumber: CB53312796
Molecular Formula: C13H19NaO2
Formula Weight: 230.28
MOL File: 1254472-97-3.mol

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PBI-4050 Sodium salt Property

storage temp.: Store at -20°C
solubility: Water : ≥ 100 mg/mL (438.10 mM);DMSO : ≥ 64 mg/mL (280.38 mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0020275
Product name: Setogepram(sodiumsalt)
Purity: 99.65%
Packaging: 5mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-0020275
Product name: Setogepram(sodiumsalt)
Purity: 99.65%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0020275
Product name: Setogepram(sodiumsalt)
Purity: 99.65%
Packaging: 50mg
Price: $1100
Updated: 2021/12/16

ChemScene

Product number: CS-0020275
Product name: Setogepram(sodiumsalt)
Purity: 99.65%
Packaging: 100mg
Price: $1600
Updated: 2021/12/16

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PBI-4050 Sodium salt Chemical Properties,Usage,Production

Uses

Fezagepras (Setogepram) sodium acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84[1]. Fezagepras sodium decreases renal, liver and pancreatic fibrosis[1][2]. Fezagepras sodium exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions[2].

in vivo

Fezagepras sodium (100 mg/kg/day; gavage from 8-20 weeks of age) markedly decreases hyperglycemia and markedly improvea glucose tolerance in type 2 diabetes eNOS^-/-db/db mice^[1].·

Animal Model:	Type 2 diabetes eNOS^-/-db/db mice^[1]
Dosage:	100 mg/kg/day
Administration:	Given via daily gavage from 8-20 weeks
Result:	Compared with vehicle-treated mice, hyperglycemia was markedly decreased, and glucose tolerance was markedly improved.

References

[1] Li Y, et al. Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control. JCI Insight. 2018 May 17;3(10). pii: 120365. DOI:10.1172/jci.insight.120365
[2] Grouix B, et al. PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway. J Pharmacol Exp Ther. 2018 Oct;367(1):71-81. DOI:10.1124/jpet.118.250068

PBI-4050 Sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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PBI-4050 Sodium salt Suppliers

China 26 United States 3 Global 29

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
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Country: China
ProdList: 86249
Advantage: 60

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
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Twochem Co.Ltd.

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Fax: QQ 3285589261
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Country: China
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Fan De(Beijing) Biotechnology Co., Ltd.

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Email: liming@bio-fount.com
Country: China
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Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

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Email: chemflowtech@sina.com
Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Shanghai hongqu biomedical technology co. LTD

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1254472-97-3, PBI-4050 Sodium saltRelated Search:

Setogepram sodium salt

PBI-4050 Sodium salt

Fezagepras (sodium)

Fezagepras sodium, 10 mM in DMSO

1254472-97-3