Sotalol D6 HCl
- Product Name
- Sotalol D6 HCl
- CAS No.
- 1246820-85-8
- Chemical Name
- Sotalol D6 HCl
- Synonyms
- Sotalol D6 HCl;[2H6]-Sotalol HCl;D6-Sotalol Hydrochloride;[2H6]- Sotalol Hydrochloride;(±)-Sotalol-d6 hydrochloride (dimethyl-d6);Sotalol hydrochloride D6 100 μg/mL in Water;(±)-Sotalol-d6 hydrochloride (dimethyl-d6) in methanol
- CBNumber
- CB53313177
- Molecular Formula
- C12H21ClN2O3S
- Formula Weight
- 308.82
- MOL File
- 1246820-85-8.mol
Sotalol D6 HCl Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble; Methanol: soluble; Water: soluble
- form
- A solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 29097
- Product name
- Sotalol-d6 (hydrochloride)
- Packaging
- 1mg
- Price
- $291
- Updated
- 2024/03/01
- Product number
- 29097
- Product name
- Sotalol-d6 (hydrochloride)
- Purity
- ≥99% deuterated forms (d<sub>1</sub>-d<sub>6</sub>);
- Packaging
- 5mg
- Price
- $1087
- Updated
- 2024/03/01
- Product number
- S677302
- Product name
- Sotalol-d6Hydrochloride
- Packaging
- 1mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 4341DN
- Product name
- Sotalol-d6Hydrochloride
- Packaging
- 1mg
- Price
- $422
- Updated
- 2021/12/16
- Product number
- CS-0112134
- Product name
- SotalolD6(hydrochloride)
- Packaging
- 5mg
- Price
- $630
- Updated
- 2021/12/16
Sotalol D6 HCl Chemical Properties,Usage,Production
Description
Sotalol-d6 is intended for use as an internal standard for the quantification of sotalol by GC- or LC-MS. Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).
Uses
A labelled potent α-adrenergic receptor antagonist. A class III antiarrythmic. It has been shown to prolong action potential and increases the refractory period.
References
[1] RANDALL LIS. Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity[J]. Journal of Medicinal Chemistry, 1990, 33 10: 2883-2891. DOI: 10.1021/jm00172a033
[2] BS M J A, PHD Allen G B, PHD. Pharmacology, pharmacodynamics and pharmacokinetics of sotalol[J]. American Journal of Cardiology, 1990, 65 2: Pages 12-21. DOI: 10.1016/0002-9149(90)90196-8
[3] KATSUHIDE KOMEICHI. Effects of N-acetylprocainamide and sotalol on ion currents in isolated guinea-pig ventricular myocytes[J]. European journal of pharmacology, 1990, 187 3: Pages 313-322. DOI: 10.1016/0014-2999(90)90358-d
Sotalol D6 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
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