(R)-methyl 2-(tert-butyldimethylsilyloxy)propanoate

Product Name: (R)-methyl 2-(tert-butyldimethylsilyloxy)propanoate
CAS No.: 171230-81-2
Chemical Name: (R)-methyl 2-(tert-butyldimethylsilyloxy)propanoate
Synonyms: (R)-methyl 2-(tert-butyldimethylsilyloxy)propanoate;Methyl (R)-2-[(tert-Butyldimethylsilyl)oxy]propanoate;methyl (2R)-2-[tert-butyl(dimethyl)silyl]oxypropanoate;(R)-2-(tert-Butyl-dimethyl-silanyloxy)-propionic acid methyl ester;Propanoic acid, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, methyl ester, (2R)-
CBNumber: CB53313490
Molecular Formula: C10H22O3Si
Formula Weight: 218.37
MOL File: 171230-81-2.mol

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(R)-methyl 2-(tert-butyldimethylsilyloxy)propanoate Property

Boiling point:: 211.4±23.0 °C(Predicted)
Density: 0.911±0.06 g/cm3(Predicted)
storage temp.: 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 301185
Product name: (R)-Methyl 2-((tert-butyldimethylsilyl)oxy)propanoate
Packaging: 250.00mg
Price: $78
Updated: 2026/05/19

Matrix Scientific

Product number: 301185
Product name: (R)-Methyl 2-((tert-butyldimethylsilyl)oxy)propanoate
Packaging: 1.00g
Price: $171
Updated: 2026/05/19

Matrix Scientific

Product number: 301185
Product name: (R)-Methyl 2-((tert-butyldimethylsilyl)oxy)propanoate
Packaging: 5.00g
Price: $446
Updated: 2026/05/19

Synthonix

Product number: M53364
Product name: (R)-Methyl 2-((tert-butyldimethylsilyl)oxy)propanoate
Purity: 97%
Packaging: 100mg
Price: $50
Updated: 2026/05/06

Synthonix

Product number: M53364
Product name: (R)-Methyl 2-((tert-butyldimethylsilyl)oxy)propanoate
Purity: 97%
Packaging: 250mg
Price: $80
Updated: 2026/05/06

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(R)-methyl 2-(tert-butyldimethylsilyloxy)propanoate Chemical Properties,Usage,Production

Synthesis

17392-83-5

18162-48-6

171230-81-2

GENERAL STEPS: A mixture of methyl D-lactate (5.1 g, 48.99 mmol), dichloromethane (50 mL), imidazole (5 g, 75 mmol), and tert-butyldimethylchlorosilane (8.85 g, 58.79 mmol) was stirred for 2 hours at room temperature. After completion of the reaction, the mixture was diluted with water and extracted three times with dichloromethane. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by medium pressure liquid chromatography (MPLC), using a petroleum ether solution of 5% ethyl acetate as eluent, to afford methyl (R)-2-((tert-butyldimethylsilyl)oxy)propionate (10.67 g, 100% yield) as a colorless oil.

References

[1] Patent: WO2015/171610, 2015, A2. Location in patent: Paragraph 000507
[2] Chemical Communications, 1997, # 13, p. 1219 - 1220
[3] Patent: WO2016/154533, 2016, A1. Location in patent: Paragraph 00176
[4] Tetrahedron Asymmetry, 2012, vol. 23, # 2, p. 117 - 123
[5] European Journal of Organic Chemistry, 2013, # 3, p. 525 - 532

(R)-methyl 2-(tert-butyldimethylsilyloxy)propanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-methyl 2-(tert-butyldimethylsilyloxy)propanoate Suppliers

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171230-81-2, (R)-methyl 2-(tert-butyldimethylsilyloxy)propanoateRelated Search:

(R)-methyl 2-(tert-butyldimethylsilyloxy)propanoate

Propanoic acid, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, methyl ester, (2R)-

(R)-2-(tert-Butyl-dimethyl-silanyloxy)-propionic acid methyl ester

methyl (2R)-2-[tert-butyl(dimethyl)silyl]oxypropanoate

Methyl (R)-2-[(tert-Butyldimethylsilyl)oxy]propanoate

171230-81-2