ChemicalBook > CAS DataBase List > GNF-6231
GNF-6231
- Product Name
- GNF-6231
- CAS No.
- 1243244-74-7
- Chemical Name
- GNF-6231
- Synonyms
- [2,4'-Bipyridine]-5-acetamide, N-[5-(4-acetyl-1-piperazinyl)-2-pyridinyl]-2',3-dimethyl-
- CBNumber
- CB53333724
- Molecular Formula
- C25H28N6O2
- Formula Weight
- 444.53
- MOL File
- 1243244-74-7.mol
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GNF-6231 Property
- Boiling point:
- 728.7±60.0 °C(Predicted)
- Density
- 1.251±0.06 g/cm3(Predicted)
- pka
- 12?+-.0.70(Predicted)
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GNF-6231 Chemical Properties,Usage,Production
Description
GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50=0.8 nM (Wnt3a Co-culture RGA). GNF-6231 demonstrated excellent pathway inhibition and induced robust antitumor efficacy in a mouse MMTV-WNT1 xenograft tumor model. Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. Wnt signaling is tightly controlled during cellular proliferation, differentiation, and embryonic morphogenesis. Aberrant activation of this pathway plays a critical role in a variety of cancers, such as cutaneous squamous cell carcinoma (SCC), breast cancer, and colorectal cancer.
GNF-6231 Preparation Products And Raw materials
Raw materials
Preparation Products
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GNF-6231 Suppliers
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