ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate

Product Name: ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate
CAS No.: 1596348-32-1
Chemical Name: ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate
Synonyms: 159142;KDOAM 21;KDM5 inhibitor C70;KDOAM-21 (KDM5-C70);KDM5-C70, 10 mM in DMSO;KDM5-C70(KDM5inhibitorC70);ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate;4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, ethyl ester;KDM5-C49,Histone Demethylase,JARID1,retinoblastoma,inhibit,KDM5 C70,KDM5-C70,KDM-5-C70,phosphorylation,KDM5C70,KDM5,Inhibitor,H3K4me3,antiproliferative
CBNumber: CB53334347
Molecular Formula: C17H28N4O3
Formula Weight: 336.42922
MOL File: 1596348-32-1.mol

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ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate Property

Boiling point:: 466.6±45.0 °C(Predicted)
Density: 1.099±0.06 g/cm3(Predicted)
storage temp.: -10 to -25°C
solubility: Chloroform: soluble; DMSO: soluble; Ethanol: soluble
pka: 8.39±0.28(Predicted)
form: Liquid
color: Light yellow to yellow
InChI: 1S/C17H28N4O3/c1-5-21(10-9-20(3)4)16(22)13-18-12-15-11-14(7-8-19-15)17(23)24-6-2/h7-8,11,18H,5-6,9-10,12-13H2,1-4H3
InChIKey: WCILOMUUNVPIKQ-UHFFFAOYSA-N
SMILES: CN(CCN(C(CNCC1=CC(C(OCC)=O)=CC=N1)=O)CC)C

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0077883
Product name: KDM5-C70
Purity: ≥98.0%
Packaging: 25mg
Price: $175
Updated: 2021/12/16

ChemScene

Product number: CS-0077883
Product name: KDM5-C70
Purity: ≥98.0%
Packaging: 100mg
Price: $645
Updated: 2021/12/16

ChemScene

Product number: CS-0077883
Product name: KDM5-C70
Purity: ≥98.0%
Packaging: 250mg
Price: $1295
Updated: 2021/12/16

DC Chemicals

Product number: DC23376
Product name: KDM5-C70
Purity: >98%
Packaging: 250mg
Price: $1300
Updated: 2021/12/16

DC Chemicals

Product number: DC23376
Product name: KDM5-C70
Purity: >98%
Packaging: 1g
Price: $2600
Updated: 2021/12/16

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ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate Chemical Properties,Usage,Production

Uses

KDOAM 21 is an inhibitor to KDM5A (Lysine Demethylase 5A) which is a protein coding gene.

Biological Activity

KDM5-C70 (KDOAM-21) corresponds to the ethyl ester precursor of a selective αKG-competitive KDM5 histone demethylase inhibitor KDM5-C49 (KDOAM-21; KDM5A/B/C/D Ki = 2/1/6.1/3.4 nM vs. KDM4C/6B/3A/2A Ki = 0.51/4.55/2.59/4.4 μM; KDM5A/B/C/D IC50 = 1.1/0.8/3.2/2.7 μM by FDH assay with [αKG] = 1 mM & [E]/[S] = 0.5/15 μM; KDM5A/B/C IC50 = 25/30/59 nM by alphaLISA with [αKG] = 25 μM & [E]/[S] = 10/100 nM). KDM5-C70 treatment selectively upregulates cellular histone H3 trimethylation on Lys4 (H3K4me3), but not on Lys9/7/36 (5 μM, 3d), and inhibits KDM5-dependent cancer growth (by 85%/MCF7/11d, 97%/BT474/24d, and 70%/ZR-75-1/24d; 5 μM).

IC 50

KDM5

ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate Suppliers

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1596348-32-1, ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinateRelated Search:

ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-(((2-methoxyethyl)(methyl)amino)methyl)-5-(4-(3-methoxyureido)phenyl)thiophene-3-carboxylate ethyl 5-(4-aMinophenyl)-2-(ethoxycarbonyl)-4-(((2-Methoxyethyl)(Methyl)aMino)Methyl)thiophene-3-carboxylate

159142

ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate

KDM5 inhibitor C70

KDOAM 21

KDM5-C49,Histone Demethylase,JARID1,retinoblastoma,inhibit,KDM5 C70,KDM5-C70,KDM-5-C70,phosphorylation,KDM5C70,KDM5,Inhibitor,H3K4me3,antiproliferative

4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, ethyl ester

KDM5-C70(KDM5inhibitorC70)

KDOAM-21 (KDM5-C70)

KDM5-C70, 10 mM in DMSO

1596348-32-1