AZD1979
- Product Name
- AZD1979
- CAS No.
- 1254035-84-1
- Chemical Name
- AZD1979
- Synonyms
- AZD1979;AZD-1979 (AZD1979;Methanone, [5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl][3-[4-(2-oxa-6-azaspiro[3.3]hept-6-ylmethyl)phenoxy]-1-azetidinyl]-;[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[3-[4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)-phenoxy]azetidin-1-yl]methanone
- CBNumber
- CB53339605
- Molecular Formula
- C25H26N4O5
- Formula Weight
- 462.5
- MOL File
- 1254035-84-1.mol
AZD1979 Property
- Boiling point:
- 636.6±65.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 8.05±0.20(Predicted)
- form
- Solid
- color
- Off-white to light yellow
- InChI
- InChI=1S/C25H26N4O5/c1-31-19-8-4-18(5-9-19)22-26-27-23(34-22)24(30)29-11-21(12-29)33-20-6-2-17(3-7-20)10-28-13-25(14-28)15-32-16-25/h2-9,21H,10-16H2,1H3
- InChIKey
- BKKPIQPFRAPEAY-UHFFFAOYSA-N
- SMILES
- C(C1=NN=C(C2=CC=C(OC)C=C2)O1)(N1CC(OC2=CC=C(CN3CC4(COC4)C3)C=C2)C1)=O
AZD1979 Chemical Properties,Usage,Production
Uses
AZD1979 is a Melanin-concentrating hormone receptor 1 (MCHr1) antagonist with an IC50 of ~12 nM.
Definition
ChEBI: AZD1979 is a carboxamide resulting from the formal condensation of the carboxy group of 5-(p-methoxyphenyl)-1,3,4-oxadiazole-2-carboxylic acid with the amino group of 3-phenoxyazetidine and in which the phenoxy group has been substituted at the para- position by a 2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl group. It is a melanin concentrating hormone receptor 1 (MCHr1) antagonist. It has a role as a melanin-concentrating hormone receptor antagonist. It is an azaspiro compound, an oxaspiro compound, an oxadiazole, a N-acylazetidine, a member of oxetanes, an aromatic ether and a carboxamide. It is a conjugate base of an AZD1979(1+).
in vivo
In DIO mice, initial AZD1979-mediate body weight loss is driven by decreasing food intake, but an additional component of preserving energy expenditure is apparent in pair-feeding and indirect calorimetry studies. AZD1979 also dose-dependently reduces body weight in dogs[1].
References
[1] Ploj K, et al. Effects of a novel potent melanin-concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs. Br J Pharmacol. 2016 Sep;173(18):2739-51. DOI:10.1111/bph.13548
AZD1979 Preparation Products And Raw materials
Raw materials
Preparation Products
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