EF-5

Product Name: EF-5
CAS No.: 152721-37-4
Chemical Name: EF-5
Synonyms: EF-5;EF5 >=98% (HPLC);EF-5, 10 mM in DMSO;inhibit,EF 5,EF-5,Inhibitor;1H-Imidazole-1-acetamide, 2-nitro-N-(2,2,3,3,3-pentafluoropropyl)-
CBNumber: CB53339650
Molecular Formula: C8H7F5N4O3
Formula Weight: 302.16
MOL File: 152721-37-4.mol

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EF-5 Property

Density: 1.66±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (413.69 mM)
form: Solid
pka: 12.32±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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EF-5 Chemical Properties,Usage,Production

Biological Activity

EF5 is a 2-nitroimidazole-based hypoxia marker corresponding to a pentafluorinated derivative of the hypoxic cell-radiation sensitizer etanidazole. Under low oxygen (hypoxic) condition, reductive activation of its 2-nitroimidazole moiety leads to enhanced EF5 adduct formation with protein thiols and reduced glutathione. The pentafluorination derivatization substantially decreases the proportion of low molecular weight hydrolytic fragmentation of the adducts, making EF5 superior to etanidazole when utilized as a hypoxia marker by immunohistological staining.

EF-5 Preparation Products And Raw materials

Raw materials

Preparation Products

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EF-5 Suppliers

China 19 United States 3 Global 22

MedChemexpress LLC

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152721-37-4, EF-5Related Search:

EF-5

1H-Imidazole-1-acetamide, 2-nitro-N-(2,2,3,3,3-pentafluoropropyl)-

EF5 >=98% (HPLC)

inhibit,EF 5,EF-5,Inhibitor

EF-5, 10 mM in DMSO

152721-37-4

C8H7F5N4O3