ChemicalBook > CAS DataBase List > L791943
L791943
- Product Name
- L791943
- CAS No.
- 192767-01-4
- Chemical Name
- L791943
- Synonyms
- L791943;L791943,L-791943;Benzenemethanol, 4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxido-4-pyridinyl)ethyl]-α,α-bis(trifluoromethyl)-
- CBNumber
- CB53339670
- Molecular Formula
- C24H17F10NO4
- Formula Weight
- 573.39
- MOL File
- 192767-01-4.mol
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L791943 Property
- Boiling point:
- 561.6±50.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 9.17±0.15(Predicted)
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L791943 Chemical Properties,Usage,Production
Uses
L791943 is a potent, selective Phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 4.2 nM.
IC 50
PDE4
References
[1] Richard Frenette, et al. Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters. Bioorg Med Chem Lett. 2002 Oct 21;12(20):3009-13. DOI:10.1016/s0960-894x(02)00615-7
[2] Guay D, et al. Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1457-61. DOI:10.1016/s0960-894x(02)00190-7
L791943 Preparation Products And Raw materials
Raw materials
Preparation Products
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L791943 Suppliers
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- China
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- Tel
- +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
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- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
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