YM-46303

Product Name: YM-46303
CAS No.: 171722-81-9
Chemical Name: YM-46303
Synonyms: YM-46303;YM46303,YM 46303
CBNumber: CB53339731
Molecular Formula: C20H23ClN2O2
Formula Weight: 358.87
MOL File: 171722-81-9.mol

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YM-46303 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO

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Hazard and Precautionary Statements (GHS)

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YM-46303 Chemical Properties,Usage,Production

Uses

YM-46303 is an mAChR antagonist which exhibits the highest affinities for M1 and M3 receptors, and selectivity for M3 over M2 receptor.

in vivo

YM-46303 shows approximately ten times higher inhibitory activity on bladder pressure in reflexly-evoked rhythmic contraction, and about 5-fold greater selectivity for urinary bladder contraction against salivary secretion in rats compared to oxybutynin. Further evaluation of antimuscarinic effects on bradycardia and pressor in pithed rats, and on tremor in mice, show that YM-46303 can be useful for the treatment of urinary urge incontinence as a bladder-selective M3 antagonist with potent activities and fewer side effects^[1]. YM-46303 shows in vivo selective inhibitory activities on bladder pressure in reflexly-evoked rhythmic contraction against oxotremorine-induced salivary secretion. In addition, YM-46303 has potent activity in a guinea pig model of methacholine-induced bronchospasm on intravenous administration^[2].

References

[1] Naito R, et al. Selective muscarinic antagonists. II. Synthesis and antimuscarinic properties of biphenylylcarbamate derivatives. Chem Pharm Bull (Tokyo). 1998 Aug;46(8):1286-94. DOI:10.1248/cpb.46.1286
[2] Nagashima S, et al. Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists. Bioorg Med Chem. 2014 Jul 1;22(13):3478-87. DOI:10.1016/j.bmc.2014.04.031

YM-46303 Preparation Products And Raw materials

Raw materials

Preparation Products

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YM-46303 Suppliers

China 8 United States 5 USA 1 Global 14

MedChemexpress LLC

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171722-81-9, YM-46303Related Search:

YM-46303

YM46303,YM 46303

171722-81-9