CYC-065

Product Name: CYC-065
CAS No.: 1070790-89-4
Chemical Name: CYC-065
Synonyms: CDK259;CPD1574;CYC065 base;Fadraciclib;CYC065, CDK259;CYC065 free base;Fadraciclib（CYC065）;Fadraciclib, 10 mM in DMSO;Fadraciclib (CYC065) ，S7371;CYC065; CYC-065; CYC 065;1070790-89-4
CBNumber: CB53339867
Molecular Formula: C21H31N7O
Formula Weight: 397.52
MOL File: 1070790-89-4.mol

More

Less

CYC-065 Property

Boiling point:: 618.3±65.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);251.55(Max Conc. mM)
form: A solid
pka: 14.62±0.20(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-7615
Product name: CYC065
Purity: 99.78%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-7615
Product name: CYC065
Purity: 99.78%
Packaging: 5mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-7615
Product name: CYC065
Purity: 99.78%
Packaging: 10mg
Price: $900
Updated: 2021/12/16

ChemScene

Product number: CS-7615
Product name: CYC065
Purity: 99.78%
Packaging: 50mg
Price: $2340
Updated: 2021/12/16

ChemScene

Product number: CS-7615
Product name: CYC065
Purity: 99.78%
Packaging: 100mg
Price: $3360
Updated: 2021/12/16

More

Less

CYC-065 Chemical Properties,Usage,Production

Uses

Fadraciclib (CYC065) is a second-generation, orally available ATP-competitive inhibitor of CDK2/CDK9 kinases[1] with IC50s of 5 and 26 nM, respectively[2].

in vivo

To evaluate the therapeutic potential of Fadraciclib as a single agent, USC-ARK-2-derived xenografts are treated daily with Fadraciclib (22.5 mg/kg) for a 3-week period. Tumor size and mouse weight are recorded two times a week. The daily administration of Fadraciclib results in a significant reduction of tumor growth compared with the vehicle-treated mice (P=0.012 starting at day 9 of the treatment). No significant weight loss is reported during the entire treatment period^[1].

IC 50

CDK2; CDK9

References

[1] Cocco E, et al. Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo. Br J Cancer. 2016 Jul 26;115(3):303-11. DOI:10.1038/bjc.2016.198
[2] Sumana Devata, et al. Molecular markers and venous thromboembolism (VTE) in acute myelogenous leukemia (AML)

CYC-065 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CYC-065 Suppliers

China 63 United States 4 USA 1 Global 68

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Mashilabs (Shanghai) Co.,Ltd.

Tel: 19916721580
Fax: QQ：3154870176
Email: mafarm@126.com
Country: China
ProdList: 4542
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4769
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2991
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1944
Advantage: 55

1070790-89-4, CYC-065Related Search:

CYC065; CYC-065; CYC 065;1070790-89-4

CDK259

CYC065 base

CPD1574

CYC065, CDK259

CYC065 free base

2-Pentanol, 3-[[6-[[(4,6-dimethyl-3-pyridinyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-, (2R,3S)-

Fadraciclib（CYC065）

Fadraciclib

(2R,3S)-3-((6-(((4,6-Dimethylpyridin-3-yl)methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)pentan-2-ol

CYC-065,Cyclin dependent kinase,CYC 065,Inhibitor,Fadraciclib,inhibit,CDK

Fadraciclib, 10 mM in DMSO

Fadraciclib (CYC065) ，S7371

1070790-89-4

api