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Sarizotan 2 HCl salt

Product Name
Sarizotan 2 HCl salt
CAS No.
177976-12-4
Chemical Name
Sarizotan 2 HCl salt
Synonyms
Sarizotan 2HCl;Sarizotan DiHCl;Sarizotan 2 HCl salt
CBNumber
CB53339913
Molecular Formula
C22H22ClFN2O
Formula Weight
384.88
MOL File
177976-12-4.mol
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Sarizotan 2 HCl salt Property

Melting point:
234-235°
alpha 
20 -65° (c = 1 in methanol)
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Hazard and Precautionary Statements (GHS)

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Sarizotan 2 HCl salt Chemical Properties,Usage,Production

Uses

Sarizotan dihydrochloride (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively[1].

IC 50

5-HT1A Receptor: 0.1 nM (IC50); Human D3 Receptor: 6.8 nM (IC50); 5-HT2A Receptor: 587 nM (IC50); 5-HT2B Receptor: 108 nM (IC50); 5-HT5A Receptor: 313 nM (IC50); Human 5-HT6 Receptor: 3300 nM (IC50); Human 5-HT7 Receptor: 10 nM (IC50)

References

[1] G D Bartoszyk, et al. Sarizotan, a Serotonin 5-HT1A Receptor Agonist and Dopamine Receptor Ligand. J Neural Transm (Vienna). 2004 Feb;111(2):113-26. DOI:10.1007/s00702-003-0094-7
[2] C Marin, et al. Local Administration of Sarizotan Into the Subthalamic Nucleus Attenuates Levodopa-Induced Dyskinesias in 6-OHDA-lesioned Rats. Psychopharmacology (Berl). 2009 Jun;204(2):241-50. DOI:10.1007/s00213-008-1452-9

Sarizotan 2 HCl salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Sarizotan 2 HCl salt Suppliers

CHINA 6 United States 1 Global 7
TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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Suzhou Zhixin Biotechnology Co., Ltd.
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0512-65118909 18100677375
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sales@szzxbio.com
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China
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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customer_service@efebio.com
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China
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TargetMol Chemicals Inc.
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15002134094
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marketing@targetmol.cn
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China
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29423
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TLC Pharmaceutical Standards Ltd.
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18012923235; 18012923235
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chinasales04@tlcstandards.com.cn
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China
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Hubei Rhema Reference Materials Technology Co., Ltd.
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15787875101
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645977340@qq.com
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China
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9660
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177976-12-4, Sarizotan 2 HCl saltRelated Search:


  • Sarizotan 2 HCl salt
  • Sarizotan 2HCl
  • Sarizotan DiHCl
  • 177976-12-4