4-(3-Hydroxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl ester

Product Name: 4-(3-Hydroxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.: 403802-41-5
Chemical Name: 4-(3-Hydroxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl ester
Synonyms: 1-Boc-4-(3-hydroxy-1-propynyl)piperidine;Tert-butyl 4-(3-Hydroxyprop-1-ynyl)piperidine-1-carboxylate;tert-Butyl 4-(3-hydroxyprop-1-yn-1-yl)piperidine-1-carboxylate;4-(3-Hydroxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(3-hydroxy-1-propynyl)-,1,1-dimethylethyl ester;1-Piperidinecarboxylic acid, 4-(3-hydroxy-1-propyn-1-yl)-, 1,1-dimethylethyl ester
CBNumber: CB53345428
Molecular Formula: C13H21NO3
Formula Weight: 239.31
MOL File: 403802-41-5.mol

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4-(3-Hydroxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl ester Property

storage temp.: 2-8°C

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Chemenu

Product number: CM252782
Product name: tert-Butyl4-(3-hydroxyprop-1-yn-1-yl)piperidine-1-carboxylate
Purity: 95%
Packaging: 1g
Price: $645
Updated: 2021/12/16

Alichem

Product number: 403802415
Product name: tert-Butyl4-(3-hydroxyprop-1-yn-1-yl)piperidine-1-carboxylate
Packaging: 1g
Price: $696.9
Updated: 2021/12/16

Chemenu

Product number: CM252782
Product name: tert-Butyl4-(3-hydroxyprop-1-yn-1-yl)piperidine-1-carboxylate
Purity: 95%
Packaging: 5g
Price: $1935
Updated: 2021/12/16

Alichem

Product number: 403802415
Product name: tert-Butyl4-(3-hydroxyprop-1-yn-1-yl)piperidine-1-carboxylate
Packaging: 5g
Price: $2173.5
Updated: 2021/12/16

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4-(3-Hydroxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

203664-61-3

403802-41-5

General procedure for the synthesis of tert-butyl 4-(3-hydroxyprop-1-yn-1-yl)piperidine-1-carboxylate from tert-butyl 4-(2,2-dibromoethenyl)piperidine-1-carboxylate: 6.0 g (16.3 mmol) of tert-butyl 4-(2,2-dibromoethenyl)piperidine-1-carboxylate was dissolved in 150 ml of THF at -78 °C and 21.4 ml ( 34.2 mmol) n-butyllithium (~1.6 M hexane solution) was added slowly. After keeping the reaction at this temperature for 2 hours, 4.9 g (16.3 mmol) of paraformaldehyde was added. The reaction mixture was then slowly warmed to room temperature and the reaction continued for 3 hours. Upon completion of the reaction, the mixture was partitioned (3 times) between water and ether. The organic phase was washed with 10% NaCl aqueous solution, dried over anhydrous Na2SO4 and then concentrated. Purification by rapid chromatography on silica gel (hexane/EtOAc 4:1) afforded 3.34 g (86% yield) of the target product, tert-butyl 4-(3-hydroxyprop-1-yn-1-yl)piperidine-1-carboxylate, with mass spectrometry (MS) revealing the molecular ion peak at 239 (M).

References

[1] Patent: US2002/68753, 2002, A1

4-(3-Hydroxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(3-Hydroxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl ester Suppliers

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403802-41-5, 4-(3-Hydroxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl esterRelated Search:

4-(3-Hydroxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl ester

tert-Butyl 4-(3-hydroxyprop-1-yn-1-yl)piperidine-1-carboxylate

1-Piperidinecarboxylic acid, 4-(3-hydroxy-1-propyn-1-yl)-, 1,1-dimethylethyl ester

Tert-butyl 4-(3-Hydroxyprop-1-ynyl)piperidine-1-carboxylate

1-Piperidinecarboxylic acid, 4-(3-hydroxy-1-propynyl)-,1,1-dimethylethyl ester

1-Boc-4-(3-hydroxy-1-propynyl)piperidine

403802-41-5