PF-06726304

Product Name: PF-06726304
CAS No.: 1616287-82-1
Chemical Name: PF-06726304
Synonyms: PF-6726304;PF-06726304;antitumor,H3K27me3,PF06726304,Karpas-422,EZH2,PF 06726304,Histone Methyltransferase,inhibit,Inhibitor,PF-06726304,Y641N;5,8-dichloro-2-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7-(3,5-dimethylisoxazol-4-yl)-3,4-dihydroisoquinolin-1(2H)-one,;1(2H)-Isoquinolinone, 5,8-dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-;5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one
CBNumber: CB53353528
Molecular Formula: C22H21Cl2N3O3
Formula Weight: 446.33
MOL File: 1616287-82-1.mol

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PF-06726304 Property

Boiling point:: 686.8±55.0 °C(Predicted)
Density: 1.333±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO : ≥ 15 mg/mL (33.61 mM)
form: powder
pka: 11.76±0.10(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0346
Product name: PF-06726304 acetate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $114
Updated: 2024/03/01

Tocris

Product number: 6169
Product name: PF-06726304 acetate
Purity: ≥97%(HPLC)
Packaging: 10
Price: $173
Updated: 2021/12/16

ChemScene

Product number: CS-8072
Product name: PF-06726304
Purity: 99.64%
Packaging: 5mg
Price: $92
Updated: 2021/12/16

ChemScene

Product number: CS-8072
Product name: PF-06726304
Purity: 99.64%
Packaging: 10mg
Price: $156
Updated: 2021/12/16

ChemScene

Product number: CS-8072
Product name: PF-06726304
Purity: 99.64%
Packaging: 25mg
Price: $360
Updated: 2021/12/16

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PF-06726304 Chemical Properties,Usage,Production

Biochem/physiol Actions

PF-06726304 is a selective inhibitor of Histone-lysine N-methyltransferase EZH2 (enhancer of Zeste homolog 2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27) and is amplified and/or overexpressed in several human cancers including breast, prostate and lymphoma. PF-06726304 is a novel structural class of EZH2 inhibitor.

PF-06726304 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06726304 Suppliers

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1616287-82-1, PF-06726304Related Search:

PF-06726304

5,8-dichloro-2-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7-(3,5-dimethylisoxazol-4-yl)-3,4-dihydroisoquinolin-1(2H)-one,

5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one

PF-6726304

1(2H)-Isoquinolinone, 5,8-dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-

antitumor,H3K27me3,PF06726304,Karpas-422,EZH2,PF 06726304,Histone Methyltransferase,inhibit,Inhibitor,PF-06726304,Y641N

1616287-82-1