KI-696

Product Name: KI-696
CAS No.: 1799974-70-1
Chemical Name: KI-696
Synonyms: KI-696;KI-696,KI696;KI696, 10 mM in DMSO;1H-Benzotriazole-5-propanoic acid, β-[3-[[(4R)-3,4-dihydro-4-methyl-1,1-dioxido-2H-5,1,2-benzoxathiazepin-2-yl]methyl]-4-methylphenyl]-7-methoxy-1-methyl-, (βS)-;(S)-3-(7-Methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-methyl-3-(((R)-4-methyl-1,1-dioxido-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepin-2-yl)methyl)phenyl)propanoic acid
CBNumber: CB53355315
Molecular Formula: C28H30N4O6S
Formula Weight: 550.63
MOL File: 1799974-70-1.mol

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KI-696 Property

Boiling point:: 760.5±70.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (227.01 mM)
form: Solid
pka: 4.28±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0020903
Product name: KI696
Purity: 99.72%
Packaging: 1mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0020903
Product name: KI696
Purity: 99.72%
Packaging: 5mg
Price: $590
Updated: 2021/12/16

ChemScene

Product number: CS-0020903
Product name: KI696
Purity: 99.72%
Packaging: 10mg
Price: $990
Updated: 2021/12/16

ChemScene

Product number: CS-0020903
Product name: KI696
Purity: 99.72%
Packaging: 25mg
Price: $1990
Updated: 2021/12/16

ChemScene

Product number: CS-0020903
Product name: KI696
Purity: 99.72%
Packaging: 50mg
Price: $3500
Updated: 2021/12/16

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KI-696 Chemical Properties,Usage,Production

Biological Activity

KI-696 is a non-cytotoxic (10 mM; BEAS-2B cells), Kelch domain-targeing (Kd ~1.3 nM) KEAP1 selective inhibitor th at effectively upregulates nuclear NRF2 level in NHBE cells (%increase/[KI-696] = 100%/10 nM and 127%/100 nM; 6 hr) and NRF2 target genes transcription by blocking KEAP1-mediated NRF2 downregulation. KI-696 (5-50 mmol/kg i.v.) upregulates NRF2 target genes transcription in r at lungs in vivo, as well as alleviate ozone-induced pulmonary inflammation and GSH depletion. KI-696 inhibits OATP1B1, BSEP, and PDE3A only at much higher concentrations (IC50 = 2.5, 4.0, 10 mM, respectively) and exhibits little or no potency toward a panel of 46 channels, enzymes, and receptors.

KI-696 Preparation Products And Raw materials

Raw materials

Preparation Products

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KI-696 Suppliers

China 38 United States 3 Global 41

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4573
Advantage: 55

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2998
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7312
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Wuhan chuang he chemical co. LTD

Tel: 15907120073
Fax: 15527109962
Email: 1261789306@qq.com
Country: China
ProdList: 1152
Advantage: 58

Hefei fuya biotechnology co. LTD

Tel: 18096409024
Email: sales02@foreversyn.com
Country: China
ProdList: 1914
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4331
Advantage: 58

1799974-70-1, KI-696Related Search:

KI-696

1H-Benzotriazole-5-propanoic acid, β-[3-[[(4R)-3,4-dihydro-4-methyl-1,1-dioxido-2H-5,1,2-benzoxathiazepin-2-yl]methyl]-4-methylphenyl]-7-methoxy-1-methyl-, (βS)-

KI-696,KI696

(S)-3-(7-Methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-methyl-3-(((R)-4-methyl-1,1-dioxido-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepin-2-yl)methyl)phenyl)propanoic acid

KI696, 10 mM in DMSO

1799974-70-1