AVN-492
- Product Name
- AVN-492
- CAS No.
- 1220646-23-0
- Chemical Name
- AVN-492
- Synonyms
- CS-2812;AVN-492;AVN-492, 10 mM in DMSO;AVN-492; AVN 492; AVN492;1220646-23-0;N2,N6,N6,5,7-Pentamethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine-2,6-diamine;3-(benzenesulfonyl)-N2,5,N6,N6,7-pentamethylpyrazolo[1,5-a]pyrimidine-2,6-diamine;Pyrazolo[1,5-a]pyrimidine-2,6-diamine, N2,N6,N6,5,7-pentamethyl-3-(phenylsulfonyl)-;inhibit,5-HT Receptor,Inhibitor,AVN-492,Serotonin Receptor,AVN 492,5-hydroxytryptamine Receptor
- CBNumber
- CB53356145
- Molecular Formula
- C17H21N5O2S
- Formula Weight
- 359.45
- MOL File
- 1220646-23-0.mol
AVN-492 Property
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO:62.5(Max Conc. mg/mL);173.88(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);69.55(Max Conc. mM)
DMF:PBS (pH 7.2) (1:20):0.04(Max Conc. mg/mL);0.11(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);2.78(Max Conc. mM) - form
- A crystalline solid
- pka
- 1.04±0.30(Predicted)
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 28079
- Product name
- AVN-492
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 28079
- Product name
- AVN-492
- Packaging
- 25mg
- Price
- $618
- Updated
- 2024/03/01
- Product number
- 28079
- Product name
- AVN-492
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 28079
- Product name
- AVN-492
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- CS-7581
- Product name
- AVN-492
- Purity
- 99.49%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
AVN-492 Chemical Properties,Usage,Production
Uses
AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM).
in vivo
In rats, the plasma, brain, and CSF concentrations of the PO administered AVN-492 are dose-dependent. The drug concentration curves for the plasma and brain are of hyperbolic shape and at all doses the brain-plasma ratio is near 11%. The drug concentration in CSF, however, is nearly linearly dependent on the dose, reaching 50% of the plasma level at 10mg/kg. In mice, the plasma and brain concentrations of AVN-492, given IV at a dose of 2 mg/kg, decreased with time but at both time points, 15 min and 60 min, the brain/plasma ratio (mean±SEM) is nearly the same, at 13.2±0.7% and 9.0±1.5%, respectively. This indicates that the steady-state concentration gradient of AVN-492 is established by at least 15 min after the drug administration[1].
IC 50
5-HT6 Receptor: 91 pM (Ki)
References
[1] Ivachtchenko AV, et al. AVN-492, A Novel Highly Selective 5-HT6R Antagonist: Preclinical Evaluation. J Alzheimers Dis. 2017;58(4):1043-1063. DOI:10.3233/JAD-161262
AVN-492 Preparation Products And Raw materials
Raw materials
Preparation Products
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