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Phe-Met-Arg-Phe amide trifluoroacetate

Product Name
Phe-Met-Arg-Phe amide trifluoroacetate
CAS No.
159237-99-7
Chemical Name
Phe-Met-Arg-Phe amide trifluoroacetate
Synonyms
Phe-Met-Arg-Phe amide trifluoroacetate;PHE-MET-ARG-PHE AMIDE TRIFLUOROACETATE?, >98%;Phe-Met-Arg-Phe amide trifluoroacetate,Phe-Met-Arg-Phe-NH2 trifluoroacetate,FMRF-NH2 trifluoroacetate?, >98%
CBNumber
CB53356170
Molecular Formula
C31H43F3N8O6S
Formula Weight
712.79
MOL File
159237-99-7.mol
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Phe-Met-Arg-Phe amide trifluoroacetate Property

storage temp. 
Store at -20°C
form 
Solid
color 
White to off-white
Water Solubility 
Water : ≥ 50 mg/mL (60.47 mM)
Sequence
H-Phe-Met-Arg-Phe-NH2
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-7708
Product name
Phe-Met-Arg-Pheamidetrifluoroacetate
Purity
≥98.0%
Packaging
5mg
Price
$96
Updated
2021/12/16
ChemScene
Product number
CS-7708
Product name
Phe-Met-Arg-Pheamidetrifluoroacetate
Purity
≥98.0%
Packaging
10mg
Price
$144
Updated
2021/12/16
ChemScene
Product number
CS-7708
Product name
Phe-Met-Arg-Pheamidetrifluoroacetate
Purity
≥98.0%
Packaging
25mg
Price
$228
Updated
2021/12/16
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Phe-Met-Arg-Phe amide trifluoroacetate Chemical Properties,Usage,Production

Uses

Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K+ current, with ED50 of 23 nM in the peptidergic caudodorsal neurons.

in vivo

Phe-Met-Arg-Phe amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min[3].

References

[1] Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28. DOI:10.1085/jgp.110.5.611
[2] Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82. DOI:10.1016/0196-9781(84)90021-4
[3] Ottlecz A, et al. Phe-Met-Arg-Phe-amide (FMRFamide) stimulated growth hormone secretion in conscious OVX rats. Neuropeptides. 1987 Feb-Mar;9(2):161-7. DOI:10.1016/0143-4179(87)90054-0

Phe-Met-Arg-Phe amide trifluoroacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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159237-99-7, Phe-Met-Arg-Phe amide trifluoroacetateRelated Search:


  • Phe-Met-Arg-Phe amide trifluoroacetate
  • Phe-Met-Arg-Phe amide trifluoroacetate,Phe-Met-Arg-Phe-NH2 trifluoroacetate,FMRF-NH2 trifluoroacetate?, >98%
  • PHE-MET-ARG-PHE AMIDE TRIFLUOROACETATE?, >98%
  • 159237-99-7