BI 882370

ChemicalBook > CAS DataBase List > BI 882370

Product Name: BI 882370
CAS No.: 1392429-79-6
Chemical Name: BI 882370
Synonyms: CS-2615;BI 882370;BI882370;BI-882370;BI-882370,Raf,BI882370,inhibit,Inhibitor,Raf kinases,BI 882370;1-Propanesulfonamide, N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-;N-(3-(5-((1-Ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide
CBNumber: CB53358255
Molecular Formula: C28H33F2N7O2S
Formula Weight: 569.67
MOL File: 1392429-79-6.mol

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BI 882370 Property

Boiling point:: 649.6±65.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:5.0(Max Conc. mg/mL);8.78(Max Conc. mM)
form: A crystalline solid
pka: 5.48±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24273
Product name: BI-882370
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 24273
Product name: BI-882370
Purity: ≥95%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 24273
Product name: BI-882370
Purity: ≥95%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 24273
Product name: BI-882370
Purity: ≥95%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

ChemScene

Product number: CS-0030522
Product name: BI-882370
Purity: 99.16%
Packaging: 50mg
Price: $550
Updated: 2021/12/16

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BI 882370 Chemical Properties,Usage,Production

Description

BI-882370 is an orally bioavailable RAF inhibitor with IC₅₀ values of 0.8, 0.8, and 0.6 nM for B-RAF^V600E, wild-type B-RAF, and C-RAF in the DFG-out inactive conformation, respectively. It is selective for RAF over a panel of kinases, including LCK, KIT, Src, LYNA, LYNB, and PDGFR (IC₅₀s = 49, 415, 485, 750, 715, and 1,220 nM, respectively). It inhibits proliferation of human B-RAF-mutant melanoma cells when used at concentrations ranging from 1 to 10 nM. It reduces tumor growth in multiple B-RAF-mutant melanoma and colorectal carcinoma mouse xenograft models when administered at a dose of 25 mg/kg twice per day. BI-882370, alone and in combination with trametinib , induces tumor regression in an A375 melanoma mouse xenograft model with no resistance developing within three or five weeks, respectively.

BI 882370 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI 882370 Suppliers

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1392429-79-6, BI 882370Related Search:

BI 882370

BI882370;BI-882370

1-Propanesulfonamide, N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-

CS-2615

BI-882370,Raf,BI882370,inhibit,Inhibitor,Raf kinases,BI 882370

N-(3-(5-((1-Ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide

1392429-79-6

C28H33F2N7O2S