ChemicalBook > CAS DataBase List > BI 882370

BI 882370

Product Name
BI 882370
CAS No.
1392429-79-6
Chemical Name
BI 882370
Synonyms
CS-2615;BI 882370;BI882370;BI-882370;BI-882370,Raf,BI882370,inhibit,Inhibitor,Raf kinases,BI 882370;1-Propanesulfonamide, N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-;N-(3-(5-((1-Ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide
CBNumber
CB53358255
Molecular Formula
C28H33F2N7O2S
Formula Weight
569.67
MOL File
1392429-79-6.mol
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BI 882370 Property

Boiling point:
649.6±65.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:5.0(Max Conc. mg/mL);8.78(Max Conc. mM)
form 
A crystalline solid
pka
5.48±0.10(Predicted)
color 
Off-white to gray
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24273
Product name
BI-882370
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
24273
Product name
BI-882370
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
24273
Product name
BI-882370
Purity
≥95%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
24273
Product name
BI-882370
Purity
≥95%
Packaging
25mg
Price
$533
Updated
2024/03/01
ChemScene
Product number
CS-0030522
Product name
BI-882370
Purity
99.16%
Packaging
50mg
Price
$550
Updated
2021/12/16
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BI 882370 Chemical Properties,Usage,Production

Description

BI-882370 is an orally bioavailable RAF inhibitor with IC50 values of 0.8, 0.8, and 0.6 nM for B-RAFV600E, wild-type B-RAF, and C-RAF in the DFG-out inactive conformation, respectively. It is selective for RAF over a panel of kinases, including LCK, KIT, Src, LYNA, LYNB, and PDGFR (IC50s = 49, 415, 485, 750, 715, and 1,220 nM, respectively). It inhibits proliferation of human B-RAF-mutant melanoma cells when used at concentrations ranging from 1 to 10 nM. It reduces tumor growth in multiple B-RAF-mutant melanoma and colorectal carcinoma mouse xenograft models when administered at a dose of 25 mg/kg twice per day. BI-882370, alone and in combination with trametinib , induces tumor regression in an A375 melanoma mouse xenograft model with no resistance developing within three or five weeks, respectively.

BI 882370 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI 882370 Suppliers

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1392429-79-6, BI 882370Related Search:


  • BI 882370
  • BI882370;BI-882370
  • 1-Propanesulfonamide, N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-
  • CS-2615
  • BI-882370,Raf,BI882370,inhibit,Inhibitor,Raf kinases,BI 882370
  • N-(3-(5-((1-Ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide
  • 1392429-79-6
  • C28H33F2N7O2S