ChemicalBook > CAS DataBase List > 4-((S)-1-(tetrahydro-2H-pyran-4-yl)ethylamino)-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamide

4-((S)-1-(tetrahydro-2H-pyran-4-yl)ethylamino)-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamide

Product Name
4-((S)-1-(tetrahydro-2H-pyran-4-yl)ethylamino)-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamide
CAS No.
2088113-98-6
Chemical Name
4-((S)-1-(tetrahydro-2H-pyran-4-yl)ethylamino)-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamide
Synonyms
AZ-31;CS-2888;AZ-31;AZ 31;AZ31;AZ-31;AZ 31;AZ31, 10 mM in DMSO;4-((S)-1-(tetrahydro-2H-pyran-4-yl)ethylamino)-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamide;(S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide;6-[6-(Methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethyl]amino]-3-quinolinecarboxamide;3-Quinolinecarboxamide, 6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethyl]amino]-
CBNumber
CB53361077
Molecular Formula
C24H28N4O3
Formula Weight
420.5
MOL File
2088113-98-6.mol
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4-((S)-1-(tetrahydro-2H-pyran-4-yl)ethylamino)-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamide Property

Boiling point:
629.8±55.0 °C(Predicted)
Density 
1.234±0.06 g/cm3(Predicted)
pka
15.36±0.30(Predicted)
form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AHH
Product number
API-1963
Product name
AZ31
Purity
AZ31
Packaging
100mg
Price
$850
Updated
2021/12/16
DC Chemicals
Product number
DC10906
Product name
AZ31
Purity
>98%
Packaging
100mg
Price
$950
Updated
2021/12/16
DC Chemicals
Product number
DC10906
Product name
AZ31
Purity
>98%
Packaging
250mg
Price
$1900
Updated
2021/12/16
DC Chemicals
Product number
DC10906
Product name
AZ31
Purity
>98%
Packaging
1g
Price
$3500
Updated
2021/12/16
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4-((S)-1-(tetrahydro-2H-pyran-4-yl)ethylamino)-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamide Chemical Properties,Usage,Production

Uses

AZ31 is a a potent, highly selective, and orally active ATM inhibitor with an IC50 of <1.2 nM for ATM enzyme, and an IC50 of 46 nM for ATM in cell. AZ31 shows excellent selectivity over ATR (>500-fold) and excellent PIKK-family selectivity and pan-kinase selectivity. AZ31 is a potent radiosensitizer in vitro, it can be used for the research of cancer[1].

in vivo

AZ31 (50-100 mg/kg; p.o. twice a day) shows low brain coverage[1].

Animal Model:Nude mice[1]
Dosage:50 and 100 mg/kg
Administration:Oral gavage; 50 and 100 mg/kg twice a day
Result:Exhibited exposure over IC50 at 0.046 μM in brain only for 2-3 hours.

IC 50

ATM: 1.2 nM (IC50); ATM: 46 nM (IC50, in cell)

References

[1] Karlin J, et al. Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Mol Cancer Ther. 2018 Aug;17(8):1637-1647. DOI:10.1158/1535-7163.MCT-17-0975

4-((S)-1-(tetrahydro-2H-pyran-4-yl)ethylamino)-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((S)-1-(tetrahydro-2H-pyran-4-yl)ethylamino)-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamide Suppliers

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2088113-98-6, 4-((S)-1-(tetrahydro-2H-pyran-4-yl)ethylamino)-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamideRelated Search:


  • 4-((S)-1-(tetrahydro-2H-pyran-4-yl)ethylamino)-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamide
  • AZ-31
  • AZ-31;AZ 31
  • (S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide
  • AZ31;AZ-31;AZ 31
  • CS-2888
  • 3-Quinolinecarboxamide, 6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethyl]amino]-
  • 6-[6-(Methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(tetrahydro-2H-pyran-4-yl)ethyl]amino]-3-quinolinecarboxamide
  • AZ31, 10 mM in DMSO
  • 2088113-98-6