Asimadoline-HCl

Product Name: Asimadoline-HCl
CAS No.: 185951-07-9
Chemical Name: Asimadoline-HCl
Synonyms: Asimadoline-HCl;EMD-61753 hydrochloride;Asimadoline Hydrochlorine;Asimadoline hydrochloride;Asimadoline hydrochloride, 10 mM in DMSO;N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-2,2-diphenylacetamide;N-((S)-2-((S)-3-Hydroxypyrrolidin-1-yl)-1-phenylethyl)-N-methyl-2,2-diphenylacetamide hydrochloride;syndrome,bowel,diabetic,EMD61753,Asimadoline,irritable,κ-opioid,δ-opioid,EMD 61753,inhibit,Asimadoline hydrochloride,EMD-61753,μ-opioid,Opioid Receptor,allodynia,Inhibitor
CBNumber: CB53363778
Molecular Formula: C27H31ClN2O2
Formula Weight: 451.01
MOL File: 185951-07-9.mol

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Asimadoline-HCl Property

storage temp.: Store at -20°C
solubility: DMSO: 240 mg/mL (532.15 mM)
form: Solid
color: Off-white to light yellow
InChIKey: GMJSLABTEURMBF-CLSOAGJSSA-N
SMILES: CN([C@H](CN1C[C@@H](O)CC1)C2=CC=CC=C2)C(C(C3=CC=CC=C3)C4=CC=CC=C4)=O.Cl

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1261
Product name: Asimadoline hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $88.3
Updated: 2026/04/30

Sigma-Aldrich

Product number: SML1261
Product name: Asimadoline hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $433
Updated: 2026/04/30

TRC

Product number: A788250
Product name: AsimadolineHydrochlorine
Packaging: 250mg
Price: $1260
Updated: 2021/12/16

ChemScene

Product number: CS-0086025
Product name: Asimadolinehydrochloride
Purity: 99.80%
Packaging: 5mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-0086025
Product name: Asimadolinehydrochloride
Purity: 99.80%
Packaging: 10mg
Price: $156
Updated: 2021/12/16

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Asimadoline-HCl Chemical Properties,Usage,Production

Uses

Asimadoline Hydrochlorine is used in the treatment of IBS, a disorder associated with pain and altered bowel function.

Biological Activity

Asimadoline is a potent and selective K-opioid agonist th at does not penetrate the blood-brain barrier. Asimadoline produces both analgesic and antidiarrheal effects.

in vivo

Asimadoline (EMD-61753 hydrochloride; 1, 5, 15 mg/kg; s.c.) acutely ameliorates both formalin-evoked hyperalgesia and tactile allodynia in diabetic rats^[3].
The absorption rate following oral administration is 80% in rats and >90% in dogs and monkeys. The metabolism of Asimadoline hydrochloride is rapid and appears similar in animals and man. Asimadoline hydrochloride has peripheral anti-inflammatory actions that are partly mediated through increase in joint fluid substance P levels^[1].
Treatment with Asimadoline hydrochloride (5 mg/kg/day; i.p.) produces marked (and sustained) attenuation of the disease with all three time regimes^[2].

Animal Model:	Adult female Sprague-Dawley rats^[3]
Dosage:	1, 5, 15 mg/kg
Administration:	SC; single dose
Result:	Acutely ameliorated both formalin-evoked hyperalgesia and tactile allodynia in diabetic rats.

IC 50

κ Opioid Receptor/KOR

Asimadoline-HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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Asimadoline-HCl Suppliers

China 32 United States 4 Global 36

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185951-07-9, Asimadoline-HClRelated Search:

Asimadoline-HCl

Asimadoline hydrochloride

Asimadoline Hydrochlorine

N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-2,2-diphenylacetamide

EMD-61753 hydrochloride

syndrome,bowel,diabetic,EMD61753,Asimadoline,irritable,κ-opioid,δ-opioid,EMD 61753,inhibit,Asimadoline hydrochloride,EMD-61753,μ-opioid,Opioid Receptor,allodynia,Inhibitor

Asimadoline hydrochloride, 10 mM in DMSO

N-((S)-2-((S)-3-Hydroxypyrrolidin-1-yl)-1-phenylethyl)-N-methyl-2,2-diphenylacetamide hydrochloride

185951-07-9