AC-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH

AC-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH Property

storage temp. 

-20°C

solubility 

5% acetic acid: 1 mg/mL || water: 1 mg/mL || DMSO: 5 mg/mL

form 

lyophilized solid

color 

white

Water Solubility 

5% acetic acid: 1mg/mL
water: 1mg/mL
DMSO: 5mg/mL

Safety

WGK Germany 

WGK 1

Storage Class

11 - Combustible Solids

Hazard and Precautionary Statements (GHS)

AC-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH Chemical Properties,Usage,Production

Uses

A highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitory peptide that contains the Antennapedia transport peptide sequence fused to the N-terminus of autocamtide inhibitory peptide-II (AIP-II). AIP-II is an AIP analog where Ala³ and Val¹⁰ are replaced by Lys and Phe residues. AIP-II is reported to be more potent than CaMK-(281-302/Ala²⁸⁶) and KN-93. Inhibits by binding to the autophosphorylation site, which is distinct from the exogenous substrate-binding site.

Biological Activity

Cell permeable: yes', 'Primary Target
cam Kinase-2', 'Product does not compete with ATP.', 'Reversible: no