ChemicalBook > CAS DataBase List > Ripretinib

Ripretinib

Product Name
Ripretinib
CAS No.
1442472-39-0
Chemical Name
Ripretinib
Synonyms
KIT/PDGFR INHIBITOR(DCC-2618);Ripretinib (DCC-2618);Ripretinib;DCC-2618 HCl;13C6]-Ripretinib;KIT/PDGFR inhibitor;Ripretinib USP/EP/BP;Ripretinib Impurity 3;Oliceridine Impurity 17;Ripretinib, 10 mM in DMSO
CBNumber
CB53365156
Molecular Formula
C24H21BrFN5O2
Formula Weight
510.36
MOL File
1442472-39-0.mol
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Ripretinib Property

Boiling point:
568.6±50.0 °C(Predicted)
Density 
1.544±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:25.0(Max Conc. mg/mL);49.0(Max Conc. mM)
form 
A solid
pka
12.15±0.70(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0044835
Product name
Ripretinib
Purity
98.90%
Packaging
5mg
Price
$210
Updated
2021/12/16
ChemScene
Product number
CS-0044835
Product name
Ripretinib
Purity
98.90%
Packaging
10mg
Price
$310
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573361
Product name
Ripretinib (DCC-2618)
Purity
>98%
Packaging
100mg
Price
$986
Updated
2021/12/16
ChemScene
Product number
CS-0044835
Product name
Ripretinib
Purity
98.90%
Packaging
50mg
Price
$1100
Updated
2021/12/16
ChemScene
Product number
CS-0044835
Product name
Ripretinib
Purity
98.90%
Packaging
100mg
Price
$1850
Updated
2021/12/16
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Ripretinib Chemical Properties,Usage,Production

Uses

Ripretinib is used in the treatment of gastrointestinal stromal tumors (GISTs).

brand name

Qinlock

General Description

Class: receptor tyrosine kinase; Treatment: GIST; Other name: DCC-2618; Elimination half-life = 15 h; Protein binding = 98.8%

Biological Activity

Ripretinib is a highly effective inhibitor of both wild-type KIT and PDGFRA, with IC50 values around 3 nM. It also targets a wide range of KIT and PDGFRA mutants in GIST. Additionally, it inhibits various tumor-driving kinases such as PDGFRβ, TIE2, VEGFR2, and BRAF.

target

Primary targets: PDGFRA, KIT

Ripretinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Ripretinib Suppliers

China 112 India 1 United States 6 Global 119
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View Lastest Price from Ripretinib manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Ripretinib 1442472-39-0
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-07-19
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Ripretinib. 1442472-39-0
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-12-31
Dideu Industries Group Limited
Product
Ripretinib 1442472-39-0
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-17

1442472-39-0, RipretinibRelated Search:

4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrate Brigatinib lenvatinib Mesylate Dabrafenib Trametinib Regorafenib Neratinib Poziotinib (HM781-36B) Dacomitinib (PF299804) Cabozantinib Malate Cediranib Maleate Crizotinib Afatinib (BIBW 2992) Lorlatinib (PF-06463922) AZD-9291 Nintedanib Ethanesulfonate Salt Olaparib Vandetanib

  • KIT/PDGFR inhibitor(DCC2618)
  • KIT/PDGFR INHIBITOR(DCC-2618)
  • Ripretinib
  • Ripretinib (DCC-2618)
  • DCC-2618; DCC 2618; DCC2618; RIPRETINIB;
  • DCC-2618;KIT/PDGFR INHIBITOR
  • KIT/PDGFR inhibitor
  • N-[4-Bromo-5-[1-ethyl-1,2-dihydro-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-N'-phenylurea
  • Urea, N-[4-bromo-5-[1-ethyl-1,2-dihydro-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-N'-phenyl-
  • 1-(4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl)-3-phenylurea
  • Ripretinib USP/EP/BP
  • DCC-2618 HCl
  • 13C6]-Ripretinib
  • Ripretinib Impurity 3
  • Oliceridine Impurity 17
  • Ripretinib, 10 mM in DMSO
  • 1442472-39-0
  • C24H21BrFN5O2
  • API