ChemicalBook > CAS DataBase List > MZ 1

MZ 1

Product Name: MZ 1
CAS No.: 1797406-69-9
Chemical Name: MZ 1
Synonyms: MZ 1;MZ-1;MZ 1;MZ-1 ，S8889;Mz1, selectively degrades BRD4;cells,MZ-1,protein,Inhibitor,Degrader,PROTACs,Epigenetic Reader Domain,BRD4,selective,degradation,LS174t,MZ 1,MZ1,inhibit;L-Prolinamide, N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CBNumber: CB53367716
Molecular Formula: C49H60ClN9O8S2
Formula Weight: 1002.64
MOL File: 1797406-69-9.mol

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MZ 1 Property

Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO:30.0(Max Conc. mg/mL);29.9(Max Conc. mM)
form: A crystalline solid
pka: 13.54±0.46(Predicted)
color: White to light yellow

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Safety

HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3365
Product name: MZ1
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $101.48
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3365
Product name: MZ1
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $471
Updated: 2025/07/31

Cayman Chemical

Product number: 21622
Product name: MZ1
Purity: ≥98%
Packaging: 500μg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 21622
Product name: MZ1
Purity: ≥98%
Packaging: 1mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 21622
Product name: MZ1
Purity: ≥98%
Packaging: 5mg
Price: $393
Updated: 2024/03/01

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MZ 1 Chemical Properties,Usage,Production

Description

MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1 induces the selective degradation of BRD4 in HeLa cells when used at 0.1-0.5 μM. At concentrations of 2-10 μM, MZ1 causes the removal of BRD2, BRD3, and BRD4. BRD protein removal is evident within four hours of adding MZ1 and persists for at least 48 hours, unless MZ1 is removed.

Uses

MZ 1, is a BRD4 protein degrader based on PROTAC technology. The Bromo- and Extra-Terminal (BET) proteins BRD2, BRD3, and BRD4 play important roles in transcriptional regulation, epigenetics, and cancer and are the targets of pan-BET selective bromodomain inhibitor JQ1.

Definition

ChEBI: MZ1 is an organic molecular entity.

storage

Store at -20°C

References

[1] MICHAEL ZENGERLE Alessio C Kwok Ho Chan. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4[J]. ACS Chemical Biology, 2015, 10 8: 1770-1777. DOI: 10.1021/acschembio.5b00216

MZ 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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MZ 1 Suppliers

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View Lastest Price from MZ 1 manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: MZ 1 1797406-69-9
Price: US $0.00/mg
Min. Order: 1mg
Purity: 98%min
Supply Ability: 500mg
Release date: 2021-08-26

1797406-69-9, MZ 1Related Search:

MZ 1

(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

MZ-1;MZ 1

L-Prolinamide, N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

cells,MZ-1,protein,Inhibitor,Degrader,PROTACs,Epigenetic Reader Domain,BRD4,selective,degradation,LS174t,MZ 1,MZ1,inhibit

Mz1, selectively degrades BRD4

MZ-1 ，S8889

1797406-69-9

1797406-69-0

C49H60ClN9O8S2