ChemicalBook > CAS DataBase List > MZ 1

MZ 1

Product Name
MZ 1
CAS No.
1797406-69-9
Chemical Name
MZ 1
Synonyms
MZ 1;MZ-1;MZ 1;Mz1, selectively degrades BRD4;cells,MZ-1,protein,Inhibitor,Degrader,PROTACs,Epigenetic Reader Domain,BRD4,selective,degradation,LS174t,MZ 1,MZ1,inhibit;L-Prolinamide, N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CBNumber
CB53367716
Molecular Formula
C49H60ClN9O8S2
Formula Weight
1002.64
MOL File
1797406-69-9.mol
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MZ 1 Property

Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO:30.0(Max Conc. mg/mL);29.9(Max Conc. mM)
form 
A crystalline solid
pka
13.54±0.46(Predicted)
color 
White to light yellow
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Safety

HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3365
Product name
MZ1
Purity
≥98% (HPLC)
Packaging
5MG
Price
$114
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3365
Product name
MZ1
Purity
≥98% (HPLC)
Packaging
25MG
Price
$457
Updated
2024/03/01
Cayman Chemical
Product number
21622
Product name
MZ1
Purity
≥98%
Packaging
500μg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
21622
Product name
MZ1
Purity
≥98%
Packaging
1mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
21622
Product name
MZ1
Purity
≥98%
Packaging
5mg
Price
$393
Updated
2024/03/01
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MZ 1 Chemical Properties,Usage,Production

Description

MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1 induces the selective degradation of BRD4 in HeLa cells when used at 0.1-0.5 μM. At concentrations of 2-10 μM, MZ1 causes the removal of BRD2, BRD3, and BRD4. BRD protein removal is evident within four hours of adding MZ1 and persists for at least 48 hours, unless MZ1 is removed.

Uses

MZ 1, is a BRD4 protein degrader based on PROTAC technology. The Bromo- and Extra-Terminal (BET) proteins BRD2, BRD3, and BRD4 play important roles in transcriptional regulation, epigenetics, and cancer and are the targets of pan-BET selective bromodomain inhibitor JQ1.

Definition

ChEBI: MZ1 is an organic molecular entity.

storage

Store at -20°C

MZ 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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MZ 1 Suppliers

China 54 United Kingdom 1 United States 7 Global 62
Shanghai Lollane Biological Technology Co.,Ltd.
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Career Henan Chemica Co
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Bide Pharmatech Ltd.
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InvivoChem
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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
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TargetMol Chemicals Inc.
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Proteintech China
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View Lastest Price from MZ 1 manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
MZ 1 1797406-69-9
Price
US $0.00/mg
Min. Order
1mg
Purity
98%min
Supply Ability
500mg
Release date
2021-08-26

1797406-69-9, MZ 1Related Search:


  • MZ 1
  • (2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
  • MZ-1;MZ 1
  • L-Prolinamide, N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
  • (2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
  • cells,MZ-1,protein,Inhibitor,Degrader,PROTACs,Epigenetic Reader Domain,BRD4,selective,degradation,LS174t,MZ 1,MZ1,inhibit
  • Mz1, selectively degrades BRD4
  • 1797406-69-9
  • C49H60ClN9O8S2