ChemicalBook > CAS DataBase List > AS2553627
AS2553627
- Product Name
- AS2553627
- CAS No.
- 1251906-10-1
- Chemical Name
- AS2553627
- Synonyms
- AS2553627;1-Piperidinepropanenitrile, 3-(dipyrrolo[2,3-b:2',3'-d]pyridin-1(6H)-yl)-4-methyl-β-oxo-, (3R,4R)-
- CBNumber
- CB53368304
- Molecular Formula
- C18H19N5O
- Formula Weight
- 321.38
- MOL File
- 1251906-10-1.mol
More
Less
AS2553627 Property
- Boiling point:
- 666.3±55.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- pka
- 6.12±0.60(Predicted)
More
Less
AS2553627 Chemical Properties,Usage,Production
Description
AS2553627 is a novel JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts. AS2553627 potently inhibited JAK kinases but showed no inhibition of other kinases, including TCR-associated molecules. In a rat cardiac transplant model, oral administration of AS2553627 alone or co-administration with a sub-therapeutic dose of tacrolimus effectively prolonged cardiac allograft survival, suggesting the efficacy in treating acute rejection. AS2553627 may be a therapeutic candidate for the prevention of not only acute but also chronic rejection in cardiac transplantation.
AS2553627 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
AS2553627 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19892
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24017
- Advantage
- 58