ChemicalBook > CAS DataBase List > JNJ-42847922

JNJ-42847922

Product Name: JNJ-42847922
CAS No.: 1293281-49-8
Chemical Name: JNJ-42847922
Synonyms: JNJ-42847922;JNJ-42847922,Cid 67116280;Seltorexant (JNJ-42847922);Seltorexant, 10 mM in DMSO;[5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone;(5-(4,6-Dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone;[5-(4,6-Dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]methanone;(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)(hexahydro-2-(4,6-dimethylpyrimidin-2-yl)pyrrolo[3,4-c]pyrrol-5(1H)-yl)methanone;[2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE;Methanone, [5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]-
CBNumber: CB53369745
Molecular Formula: C21H22FN7O
Formula Weight: 407.44
MOL File: 1293281-49-8.mol

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JNJ-42847922 Property

Boiling point:: 667.7±65.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (613.59 mM)
pka: 6.50±0.50(Predicted)
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0030510
Product name: Seltorexant
Purity: 99.51%
Packaging: 100mg
Price: $1432
Updated: 2021/12/16

ChemScene

Product number: CS-0030510
Product name: Seltorexant
Purity: 99.51%
Packaging: 250mg
Price: $2386
Updated: 2021/12/16

Chemenu

Product number: CM337143
Product name: [2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone
Purity: 95%+
Packaging: 250mg
Price: $4343
Updated: 2021/12/16

Chemenu

Product number: CM337143
Product name: [2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone
Purity: 95%+
Packaging: 100mg
Price: $2234
Updated: 2021/12/16

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JNJ-42847922 Chemical Properties,Usage,Production

Description

Seltorexant, also known as JNJ-42847922 and MIN-202, is a potent OX2R antagonist that has been shown to promote sleep in various species. JNJ-42847922 had an approximate 2-log selectivity ratio versus the human orexin-1 receptor. Ex vivo receptor binding studies demonstrated that JNJ-42847922 quickly occupied OX2R binding sites in the rat brain after oral administration and rapidly cleared from the brain. Seltorexant shows antidepressant and sleep-promoting effects in patients with major depressive disorder. JNJ-42847922 induces somnolence in healthy subjects without residual central effects.

Uses

Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1].

in vivo

Seltorexant (JNJ-42847922) (3-30 mg/kg; p.o.) dose-dependently induces and prolongs sleep in male Sprague-Dawley rats^[1].
The sleep-promoting effects of Seltorexant (30 mg/kg; p.o.; per day for 7 days) are maintained upon 7-day repeated dosing in rats^[1].

Animal Model:	Male Sprague-Dawley rats (350-450 g)^[1]
Dosage:	30 mg/kg
Administration:	p.o.; per day for 7 days
Result:	The reduced sleep onset (non–rapid eye movement (NREM) latency) and the increased NREM sleep duration were maintained upon 7-day repeated dosing with JNJ-42847922. The prolongation of NREM sleep time was due to a significant increase in NREM bout duration throughout the treatment period assessed on D1 and D7. Rapid eye movement (REM) sleep was only marginally affected on D4 of treatment, resulting in a small but significant reduction in REM sleep latency and an increase in REM sleep duration.

IC 50

human OX2R: 8.0 (pKi); rat OX2R: 8.1 (pKi)

References

[1] Bonaventure P, et al. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia. J Pharmacol Exp Ther. 2015 Sep;354(3):471-82. DOI:10.1124/jpet.115.225466

JNJ-42847922 Preparation Products And Raw materials

Raw materials

Preparation Products

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JNJ-42847922 Suppliers

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View Lastest Price from JNJ-42847922 manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: Seltorexant 1293281-49-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-11-12

1293281-49-8, JNJ-42847922Related Search:

JNJ-40411813 JNJ-38431055 JNJ-64619178

[2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE

JNJ-42847922

JNJ-42847922,Cid 67116280

[5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone

Methanone, [5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]-

Seltorexant (JNJ-42847922)

Hypocretin Receptor,JNJ42847922,HCRT Receptor,Orexin Receptor (OX Receptor),Seltorexant,movement,barrier,insomnia,somnolence,eye,blood-brain,inhibit,rapid,selective,sleep,JNJ 42847922,Inhibitor

(5-(4,6-Dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Seltorexant, 10 mM in DMSO

(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)(hexahydro-2-(4,6-dimethylpyrimidin-2-yl)pyrrolo[3,4-c]pyrrol-5(1H)-yl)methanone

[5-(4,6-Dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]methanone

1293281-49-8

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