Xanthohumol I

Xanthohumol I Property

Boiling point:

643.5±55.0 °C(Predicted)

Density 

1.332±0.06 g/cm3(Predicted)

pka

7.47±0.40(Predicted)

Hazard and Precautionary Statements (GHS)

Xanthohumol I Chemical Properties,Usage,Production

Uses

Xanthohumol I, a chalkone, is a derivative of Xanthohumol (HY-N1067). Xanthohumol is a Cholinesterase (ChE) inhibitor, which inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) wih IC50s of 71.34 μM and 32.67 μM, respectively. The hydroxy compound of Xanthohumol (3-hydroxy-xanthohumol), also shoes inhibitory effect on AChE and BChE with IC50s of 51.25 μM and 63.07 μM[1].

IC 50

AChE; BChE

References

[1] Orhan IE, et al. Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives. Phytomedicine. 2018 Mar 15;42:25-33. DOI:10.1016/j.phymed.2018.03.009