3-Azidopropanoic acid NHS ester
- Product Name
- 3-Azidopropanoic acid NHS ester
- CAS No.
- 850180-76-6
- Chemical Name
- 3-Azidopropanoic acid NHS ester
- Synonyms
- N3-C2-NHS ester;3-Azidopropanoic acid NHS ester;(2,5-Dioxopyrrolidin-1-yl) 3-azidopropanoate;3-azidopropanoate-N-hydroxysuccinimide ester;(2,5-Dioxopyrrolidin-1-yl) 3-azidopropanoate - [A19129]
- CBNumber
- CB53373524
- Molecular Formula
- C7H8N4O4
- Formula Weight
- 212.17
- MOL File
- 850180-76-6.mol
3-Azidopropanoic acid NHS ester Property
- solubility
- Soluble in DMSO, DCM, DMF
- form
- Oil
- color
- Colorless to off-white
N-Bromosuccinimide Price
- Product number
- A19129
- Product name
- (2,5-Dioxopyrrolidin-1-yl)3-azidopropanoate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- A19129
- Product name
- (2,5-Dioxopyrrolidin-1-yl)3-azidopropanoate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0105078
- Product name
- N3-C2-NHSester
- Packaging
- 100mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- A19129
- Product name
- (2,5-Dioxopyrrolidin-1-yl)3-azidopropanoate
- Purity
- 95%
- Packaging
- 500mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- A19129
- Product name
- (2,5-Dioxopyrrolidin-1-yl)3-azidopropanoate
- Purity
- 95%
- Packaging
- 1g
- Price
- $820
- Updated
- 2021/12/16
3-Azidopropanoic acid NHS ester Chemical Properties,Usage,Production
Description
3-Azidopropanoic acid NHS ester is an azidopropanoic acid linker that contains an NHS ester group. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkyne, DBCO and BCN. The NHS ester can react with other primary amines to label proteins and antibodies.
Uses
N3-C2-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C2-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
Non-cleavable Linker
References
[1] Gregson SJ, et al. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507. DOI:10.1021/acs.jmedchem.7b00736
3-Azidopropanoic acid NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Azidopropanoic acid NHS ester manufacturers
- Product
- N3-C2-NHS ester 850180-76-6
- Price
- US $0.00/mg
- Min. Order
- 250mg
- Purity
- >95.00%
- Supply Ability
- 250mg
- Release date
- 2024-03-22