DBCO-PEG4-NHS ester

Product Name: DBCO-PEG4-NHS ester
CAS No.: 2100306-58-7
Chemical Name: DBCO-PEG4-NHS ester
Synonyms: DBCO-NHCO-PEG4-NHS ester;4,7,10,13-Tetraoxa-17-azaeicosanoic acid, 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-16,20-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester;2,5-dioxopyrrolidin-1-yl 1-[(3-{2-azatricyclo[10.4.0.0\\u2074,\\u2079]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-3-oxopropyl)carbamoyl]-3,6,9,12-tetraoxapentadecan-15-oate
CBNumber: CB53373605
Molecular Formula: C34H39N3O10
Formula Weight: 649.69
MOL File: 2100306-58-7.mol

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DBCO-PEG4-NHS ester Property

Density: 1.33±0.1 g/cm3(Predicted)
pka: 15.14±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23726
Product name: DBCO-NHCO-PEG4-NHSester
Purity: 98%
Packaging: 25mg
Price: $290
Updated: 2021/12/16

BroadPharm

Product number: BP-23726
Product name: DBCO-NHCO-PEG4-NHSester
Purity: 98%
Packaging: 100mg
Price: $680
Updated: 2021/12/16

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DBCO-PEG4-NHS ester Chemical Properties,Usage,Production

Description

DBCO-NHCO-PEG4-NHS ester is a PEG linker containing NHS ester that is able to react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and can also provide a long and flexible connection that minimizes steric hindrance during ligation. DBCO is commonly used for copper-free Click Chemistry reactions.

Biological Activity

DBCO-NHCO-PEG4-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. Also it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Alkyl/ether

DBCO-PEG4-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-PEG4-NHS ester Suppliers

China 23 United States 3 Global 26

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 50266790 18317173152
Fax: QQ3382968513
Email: Hailey@shsendpharm.com
Country: China
ProdList: 904
Advantage: 55

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80534353 19917294565
Email: et@chemextension.com
Country: China
ProdList: 3828
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
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Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Hangzhou Huarong Pharm Co., Ltd.

Tel: 571-86758373 +8613588754946
Fax: 0086-571-81131109
Email: sales@huarongpharm.com
Country: CHINA
ProdList: 3148
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Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

Tel: 13892832556
Email: 2440688701@qq.com
Country: China
ProdList: 1995
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Shanghai Minhan Pharmaceutical Technology Co., Ltd.

Tel: 17612188245
Fax: QQ 2816925681
Email: 2816925681@qq.com
Country: China
ProdList: 9957
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Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988941452
Fax: QQ：3283937693
Email: YN_research@163.com
Country: China
ProdList: 2999
Advantage: 58

2100306-58-7, DBCO-PEG4-NHS esterRelated Search:

DBCO-NHCO-PEG4-NHS ester

4,7,10,13-Tetraoxa-17-azaeicosanoic acid, 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-16,20-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester

2,5-dioxopyrrolidin-1-yl 1-[(3-{2-azatricyclo[10.4.0.0\\u2074,\\u2079]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-3-oxopropyl)carbamoyl]-3,6,9,12-tetraoxapentadecan-15-oate

2100306-58-7

C34H39N3O10