DBCO-PEG4-NHS ester
- Product Name
- DBCO-PEG4-NHS ester
- CAS No.
- 2100306-58-7
- Chemical Name
- DBCO-PEG4-NHS ester
- Synonyms
- DBCO-NHCO-PEG4-NHS ester;4,7,10,13-Tetraoxa-17-azaeicosanoic acid, 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-16,20-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester;2,5-dioxopyrrolidin-1-yl 1-[(3-{2-azatricyclo[10.4.0.0\\u2074,\\u2079]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-3-oxopropyl)carbamoyl]-3,6,9,12-tetraoxapentadecan-15-oate
- CBNumber
- CB53373605
- Molecular Formula
- C34H39N3O10
- Formula Weight
- 649.69
- MOL File
- 2100306-58-7.mol
DBCO-PEG4-NHS ester Property
- Density
- 1.33±0.1 g/cm3(Predicted)
- pka
- 15.14±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-23726
- Product name
- DBCO-NHCO-PEG4-NHSester
- Purity
- 98%
- Packaging
- 25mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- BP-23726
- Product name
- DBCO-NHCO-PEG4-NHSester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $680
- Updated
- 2021/12/16
DBCO-PEG4-NHS ester Chemical Properties,Usage,Production
Description
DBCO-NHCO-PEG4-NHS ester is a PEG linker containing NHS ester that is able to react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and can also provide a long and flexible connection that minimizes steric hindrance during ligation. DBCO is commonly used for copper-free Click Chemistry reactions.
Biological Activity
DBCO-NHCO-PEG4-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. Also it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
| Alkyl/ether
|
DBCO-PEG4-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
DBCO-PEG4-NHS ester Suppliers
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