S-Facinicline

Product Name: S-Facinicline
CAS No.: 677305-02-1
Chemical Name: S-Facinicline
Synonyms: RG3487;S-Facinicline;RG3487 hydrochloride;Facinicline hydrochloride;Inhibitor,nAChR,serotonin 3 receptor,Nicotinic acetylcholine receptors,Serotonin Receptor,5-HT Receptor,inhibit,recognition,5-hydroxytryptamine Receptor,Facinicline,Facinicline hydrochloride,receptor,RG-3487,memory,RG 3487,nicotinic
CBNumber: CB53379708
Molecular Formula: C15H19ClN4O
Formula Weight: 306.79056
MOL File: 677305-02-1.mol

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S-Facinicline Property

storage temp.: Store at -20°C
solubility: DMSO: 125 mg/mL (407.44 mM); Methanol: 25 mg/mL (81.49 mM)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0081613
Product name: Facinicline(hydrochloride)
Purity: 99.93%
Packaging: 5mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0081613
Product name: Facinicline(hydrochloride)
Purity: 99.93%
Packaging: 10mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0081613
Product name: Facinicline(hydrochloride)
Purity: 99.93%
Packaging: 50mg
Price: $1400
Updated: 2021/12/16

ChemScene

Product number: CS-0081613
Product name: Facinicline(hydrochloride)
Purity: 99.93%
Packaging: 100mg
Price: $2200
Updated: 2021/12/16

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S-Facinicline Chemical Properties,Usage,Production

Biological Activity

Facinicline hydrochloride (RG3487 hydrochloride) is an orally active partial agonist of the nicotinic α7 receptor with a Ki of 6 nM for human nAChR. It (RG3487 hydrochloride) improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride has a Ki value of 1.2 nM for the 5-HT3 receptor (antagonist).

in vitro

Facinicline (RG3487) activates human α7 nAChRs with an EC ₅₀ of 0.8 μM (oocytes) and 7.7 μM (QM7 cells).
It (RG3487) exhibits antagonist properties at the serotonin 3 receptor (IC ₅₀ 2.8 nM (oocytes), 32.7 nM (N1E-115 cells)).

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in vivo

Facinicline (RG3487) improves object recognition memory in rats after acute [minimally effective dose (MED) 1.0 mg/kg po] or repeated (10 day) administration at brain and plasma concentrations in the low-nanomolar range.
RG3487 (0.1–10 mg/kg po) selectively enhances object recognition memory.

< td class="col1 fwb"> Result:

Animal Model:	Male Sprague-Dawley rats.
Dosage:	0.1-10 mg/kg (Pharmacokinetic Analysis ).
Administration:	Orally.
The mean C _max was typically observed between 0.5 and 4 h.

target

5-HT ₃ Receptor

1.2 nM (Ki)

α7

< span> 6 nM (Ki)

S-Facinicline Preparation Products And Raw materials

Raw materials

Preparation Products

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S-Facinicline Suppliers

China 12 United States 3 Global 15

Xenoah Pharmaceutical Inc.

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677305-02-1, S-FaciniclineRelated Search:

S-Facinicline

Facinicline hydrochloride

RG3487

RG3487 hydrochloride

Inhibitor,nAChR,serotonin 3 receptor,Nicotinic acetylcholine receptors,Serotonin Receptor,5-HT Receptor,inhibit,recognition,5-hydroxytryptamine Receptor,Facinicline,Facinicline hydrochloride,receptor,RG-3487,memory,RG 3487,nicotinic

677305-02-1