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S-Facinicline

Product Name
S-Facinicline
CAS No.
677305-02-1
Chemical Name
S-Facinicline
Synonyms
RG3487;S-Facinicline;RG3487 hydrochloride;Facinicline hydrochloride;Facinicline hydrochloride, 10 mM in DMSO;Inhibitor,nAChR,serotonin 3 receptor,Nicotinic acetylcholine receptors,Serotonin Receptor,5-HT Receptor,inhibit,recognition,5-hydroxytryptamine Receptor,Facinicline,Facinicline hydrochloride,receptor,RG-3487,memory,RG 3487,nicotinic
CBNumber
CB53379708
Molecular Formula
C15H19ClN4O
Formula Weight
306.79056
MOL File
677305-02-1.mol
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S-Facinicline Property

storage temp. 
Store at -20°C
solubility 
DMSO: 125 mg/mL (407.44 mM); Methanol: 25 mg/mL (81.49 mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0081613
Product name
Facinicline(hydrochloride)
Purity
99.93%
Packaging
5mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0081613
Product name
Facinicline(hydrochloride)
Purity
99.93%
Packaging
10mg
Price
$500
Updated
2021/12/16
ChemScene
Product number
CS-0081613
Product name
Facinicline(hydrochloride)
Purity
99.93%
Packaging
50mg
Price
$1400
Updated
2021/12/16
ChemScene
Product number
CS-0081613
Product name
Facinicline(hydrochloride)
Purity
99.93%
Packaging
100mg
Price
$2200
Updated
2021/12/16
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S-Facinicline Chemical Properties,Usage,Production

Biological Activity

Facinicline hydrochloride (RG3487 hydrochloride) is an orally active partial agonist of the nicotinic α7 receptor with a Ki of 6 nM for human nAChR. It (RG3487 hydrochloride) improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride has a Ki value of 1.2 nM for the 5-HT3 receptor (antagonist).

in vitro

Facinicline (RG3487) activates human α7 nAChRs with an EC 50 of 0.8 μM (oocytes) and 7.7 μM (QM7 cells).
It (RG3487) exhibits antagonist properties at the serotonin 3 receptor (IC 50 2.8 nM (oocytes), 32.7 nM (N1E-115 cells)).

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in vivo

Facinicline (RG3487) improves object recognition memory in rats after acute [minimally effective dose (MED) 1.0 mg/kg po] or repeated (10 day) administration at brain and plasma concentrations in the low-nanomolar range.
RG3487 (0.1–10 mg/kg po) selectively enhances object recognition memory.

< td class="col1 fwb"> Result:
Animal Model: Male Sprague-Dawley rats.
Dosage: 0.1-10 mg/kg (Pharmacokinetic Analysis ).
Administration: Orally.
The mean C max was typically observed between 0.5 and 4 h.

target

5-HT 3 Receptor

1.2 nM (Ki)

α7

< span> 6 nM (Ki)

S-Facinicline Preparation Products And Raw materials

Raw materials

Preparation Products

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S-Facinicline Suppliers

China 16 United States 3 Global 19
Xenoah Pharmaceutical Inc.
Tel
0512-6956-1983
Email
info@xenoah.com
Country
China
ProdList
296
Advantage
58
SuZhou Medinoah Co.,LTD.
Tel
0512-69561983 13914027025
Fax
0512-69561982
Email
zhang_q@medinoah.com
Country
China
ProdList
3669
Advantage
58
Shanxi Xuanran Import and Export Trade Co., Ltd.
Tel
+8617735180244
Email
mike_yan@xuanranglobal.com
Country
CHINA
ProdList
4017
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ：2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24641
Advantage
58
Suzhou Meishi Biotechnology Co., Ltd.
Tel
1173954148q
Email
meishipharma@126.com
Country
China
ProdList
20033
Advantage
58
Abosyn
Tel
0512-69561983 13914027025
Email
he_qf@medinoah.com
Country
China
ProdList
3001
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
Advantage
58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
4997
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
Advantage
58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
47240
Advantage
58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd
Tel
+8618235132063
Email
sales@tihondan.com
Country
China
ProdList
3767
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6743
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58

677305-02-1, S-FaciniclineRelated Search:


  • S-Facinicline
  • Facinicline hydrochloride
  • RG3487
  • RG3487 hydrochloride
  • Inhibitor,nAChR,serotonin 3 receptor,Nicotinic acetylcholine receptors,Serotonin Receptor,5-HT Receptor,inhibit,recognition,5-hydroxytryptamine Receptor,Facinicline,Facinicline hydrochloride,receptor,RG-3487,memory,RG 3487,nicotinic
  • Facinicline hydrochloride, 10 mM in DMSO
  • 677305-02-1