3,5-Dibromotoluene
- Product Name
- 3,5-Dibromotoluene
- CAS No.
- 1611-92-3
- Chemical Name
- 3,5-Dibromotoluene
- Synonyms
- 1,3-dibromo-5-methylbenzene;3,5-DibromotoL;5-DibroMotoluene;3,5-DIBROMOTOLUENE;3,5-Dibromotoluene>Toluene, 3,5-dibromo-;3,5-Dibromotoluene 97%;3,5-Dibromotoluene, 98+%;3,5-DibroMotoluene, 98% 5GR;Benzene, 1,3-dibromo-5-methyl-
- CBNumber
- CB5337994
- Molecular Formula
- C7H6Br2
- Formula Weight
- 249.93
- MOL File
- 1611-92-3.mol
3,5-Dibromotoluene Property
- Melting point:
- 34-38 °C (lit.)
- Boiling point:
- 246 °C (lit.)
- Density
- 1.8246 (rough estimate)
- refractive index
- 1.6075 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Yellow to Orange
- BRN
- 1928685
- InChI
- InChI=1S/C7H6Br2/c1-5-2-6(8)4-7(9)3-5/h2-4H,1H3
- InChIKey
- DPKKOVGCHDUSAI-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC(C)=CC(Br)=C1
- CAS DataBase Reference
- 1611-92-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzene, 1,3-dibromo-5-methyl-(1611-92-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D3376
- Product name
- 3,5-Dibromotoluene
- Packaging
- 5G
- Price
- $19
- Updated
- 2025/07/31
- Product number
- D3376
- Product name
- 3,5-Dibromotoluene
- Packaging
- 25G
- Price
- $75
- Updated
- 2025/07/31
- Product number
- D426163
- Product name
- 3,5-Dibromotoluene
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- JK409575
- Product name
- 3,5-Dibromotoluene
- Purity
- 98%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- J90826
- Product name
- 3,5-Dibromotoluene
- Packaging
- 25g
- Price
- $25
- Updated
- 2021/12/16
3,5-Dibromotoluene Chemical Properties,Usage,Production
Chemical Properties
slightly yellow crystalline solid
Uses
3,5-Dibromotoluene was used in the preparation of 3,5-bis(diphenylphosphinothioyl)toluene.
General Description
3,5-Dibromotoluene is a halogenated toluene and its electric moment was evaluated.
Synthesis
6968-24-7
1611-92-3
The general procedure for the synthesis of 3,5-dibromotoluene from 2,6-dibromo-4-methylaniline was as follows: 1.5 L of water was added to a 5 L reaction flask and cooled to 0-5 °C in an ice bath. Under stirring conditions, 500 g of 2,6-dibromo-4-methylaniline was added in five batches, keeping the temperature between 0-5 °C to form a light yellow suspension. The temperature was controlled not to exceed 5 °C. Sodium nitrite solution (156 g of sodium nitrite dissolved in 500 mL of water) was added slowly, a small amount of reddish brown gas was released during the reaction, and the solid was gradually dissolved. After the addition was completed, stirring was continued at 0-5°C for 30 min, and the reaction solution became a transparent liquid with some foam on the surface and a small amount of black solid attached to the wall of the bottle. Subsequently, hypophosphite solution (prepared by mixing 524 g of sodium hypophosphite monohydrate and 601 g of 30% hydrochloric acid, and filtered to remove undissolved sodium chloride solid after mixing for 1 hr) was added slowly and dropwise at 0-5 °C. After completion of the dropwise addition, the reaction was maintained at 0-5°C with stirring for 5 hours. The ice bath was removed to allow the reaction temperature to rise rapidly to 15-20 °C and stirring was continued for 16 hours. The amount of diazonium salt intermediate remaining in the reaction solution was detected as 0.87% by HPLC. The reaction mixture was filtered under reduced pressure and washed with water to give 570 g of wet product. The wet product was mixed with 800 mL of methanol and heated to 50 °C with stirring until completely dissolved and layered. The heating was stopped and the stirring was cooled to 0-10 °C, and 514 g of wet product was obtained by filtration. The wet product was dried under reduced pressure at 30 °C to give 440 g of the yellow solid product 3,5-dibromotoluene (HPLC purity: 94%, yield: 93%), which could be used directly in the next step of the reaction.The NMR spectrum of 3,5-dibromotoluene is shown in Figure 2.
References
[1] Patent: CN108250046, 2018, A. Location in patent: Paragraph 0053; 0060; 0061; 0062
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 12, p. 1866 - 1882
[3] Journal of Medicinal Chemistry, 2001, vol. 44, # 12, p. 1866 - 1882
[4] Chemische Berichte, 1880, vol. 13, p. 963
[5] Chemische Berichte, 1881, vol. 14, p. 417
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View Lastest Price from 3,5-Dibromotoluene manufacturers
- Product
- 3,5-dibromotoluene 1611-92-3
- Price
- US $45.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20 tons
- Release date
- 2019-12-24
- Product
- 3,5-Dibromotoluene 1611-92-3
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-21
- Product
- 3,5-Dibromotoluene 1611-92-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13