Seclidemstat

Product Name: Seclidemstat
CAS No.: 1423715-37-0
Chemical Name: Seclidemstat
Synonyms: SP2577;SP 2577;SP-2577;Seclidemstat;Seclidemstat(SP-2577);SP-2577;SP2577;SP 2577;Seclidemstat, 10 mM in DMSO;(E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-((4-methylpiperazin-1-yl)sulfonyl)benzohydrazide;Benzoic acid, 3-[(4-methyl-1-piperazinyl)sulfonyl]-, (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide;SP2577,Inhibitor,replication,reversible,SWI/SNF,SP 2577,complex,Seclidemstat,antitumor,Ewing,Histone Demethylase,DNA,inhibit,immunity,Sarcoma
CBNumber: CB53383794
Molecular Formula: C20H23ClN4O4S
Formula Weight: 450.94
MOL File: 1423715-37-0.mol

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Seclidemstat Property

Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (221.76 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 7.96±0.43(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0039281
Product name: Seclidemstat
Purity: 98.78%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0039281
Product name: Seclidemstat
Purity: 98.78%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0039281
Product name: Seclidemstat
Purity: 98.78%
Packaging: 25mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0039281
Product name: Seclidemstat
Purity: 98.78%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0039281
Product name: Seclidemstat
Purity: 98.78%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

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Seclidemstat Chemical Properties,Usage,Production

Uses

Seclidemstat is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat can be used for the research of Ewing Sarcoma[1][2].

IC 50

KDM1/LSD1

References

[1] Dai XJ, et al. Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1 [published correction appears in J Med Chem. 2021 May 13;64(9):6410-6411]. J Med Chem. 2021;64(5):2466-2488. DOI:10.1021/acs.jmedchem.0c02176
[2] Soldi R, et al. The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer. PLoS One. 2020;15(7):e0235705. Published 2020 Jul 10. DOI:10.1371/journal.pone.0235705

Seclidemstat Preparation Products And Raw materials

Raw materials

Preparation Products

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Seclidemstat Suppliers

China 76 United States 4 Global 80

Sichuan Wei Keqi Biological Technology Co., Ltd.

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Chuzhou KeMail Chemical Technology Co., Ltd

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View Lastest Price from Seclidemstat manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Seclidemstat 1423715-37-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-29

1423715-37-0, SeclidemstatRelated Search:

Seclidemstat

SP 2577

SP2577

SP-2577

SP-2577;SP2577;SP 2577

Seclidemstat(SP-2577)

Benzoic acid, 3-[(4-methyl-1-piperazinyl)sulfonyl]-, (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide

(E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-((4-methylpiperazin-1-yl)sulfonyl)benzohydrazide

SP2577,Inhibitor,replication,reversible,SWI/SNF,SP 2577,complex,Seclidemstat,antitumor,Ewing,Histone Demethylase,DNA,inhibit,immunity,Sarcoma

Seclidemstat, 10 mM in DMSO

1423715-37-0

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