Seclidemstat

Product Name: Seclidemstat
CAS No.: 1423715-37-0
Chemical Name: Seclidemstat
Synonyms: SP2577;SP 2577;SP-2577;Seclidemstat;Seclidemstat(SP-2577);SP-2577;SP2577;SP 2577;Seclidemstat, 10 mM in DMSO;(E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-((4-methylpiperazin-1-yl)sulfonyl)benzohydrazide;Benzoic acid, 3-[(4-methyl-1-piperazinyl)sulfonyl]-, (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide;SP2577,Inhibitor,replication,reversible,SWI/SNF,SP 2577,complex,Seclidemstat,antitumor,Ewing,Histone Demethylase,DNA,inhibit,immunity,Sarcoma
CBNumber: CB53383794
Molecular Formula: C20H23ClN4O4S
Formula Weight: 450.94
MOL File: 1423715-37-0.mol

More

Less

Seclidemstat Property

Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (221.76 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 7.96±0.43(Predicted)
color: Off-white to yellow

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0039281
Product name: Seclidemstat
Purity: 98.78%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0039281
Product name: Seclidemstat
Purity: 98.78%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0039281
Product name: Seclidemstat
Purity: 98.78%
Packaging: 25mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0039281
Product name: Seclidemstat
Purity: 98.78%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0039281
Product name: Seclidemstat
Purity: 98.78%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

More

Less

Seclidemstat Chemical Properties,Usage,Production

Uses

Seclidemstat is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat can be used for the research of Ewing Sarcoma[1][2].

IC 50

KDM1/LSD1

References

[1] Dai XJ, et al. Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1 [published correction appears in J Med Chem. 2021 May 13;64(9):6410-6411]. J Med Chem. 2021;64(5):2466-2488. DOI:10.1021/acs.jmedchem.0c02176
[2] Soldi R, et al. The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer. PLoS One. 2020;15(7):e0235705. Published 2020 Jul 10. DOI:10.1371/journal.pone.0235705

Seclidemstat Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Seclidemstat Suppliers

China 80 United States 4 Global 84

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7777
Advantage: 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 977
Advantage: 55

Shanghai Biolang biotechnology Co.,Ltd

Tel: 17764003753
Fax: 13669031409
Email: 2326587775@qq.com
Country: China
ProdList: 188
Advantage: 55

Shanghai Biolang biotechnology Co.,Ltd

Tel: 17764003753
Fax: 13669031409
Email: 2326587775@qq.com
Country: China
ProdList: 188
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2992
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9550
Advantage: 58

More

Less

View Lastest Price from Seclidemstat manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Seclidemstat 1423715-37-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-29

1423715-37-0, SeclidemstatRelated Search:

Seclidemstat

SP 2577

SP2577

SP-2577

SP-2577;SP2577;SP 2577

Seclidemstat(SP-2577)

Benzoic acid, 3-[(4-methyl-1-piperazinyl)sulfonyl]-, (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide

(E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-((4-methylpiperazin-1-yl)sulfonyl)benzohydrazide

SP2577,Inhibitor,replication,reversible,SWI/SNF,SP 2577,complex,Seclidemstat,antitumor,Ewing,Histone Demethylase,DNA,inhibit,immunity,Sarcoma

Seclidemstat, 10 mM in DMSO

1423715-37-0

API