E3 ligase Ligand-Linker Conjugates 5

Product Name: E3 ligase Ligand-Linker Conjugates 5
CAS No.: 2097971-11-2
Chemical Name: E3 ligase Ligand-Linker Conjugates 5
Synonyms: VH032-PEG3-NH2 hydrochloride;(S,R,S)-AHPC-PEG3-NH2 hydrochloride;E3 ligase Ligand-Linker Conjugates 5;(S,R,S)-AHPC-PEG3-NH2 hydrochloride >=95%;VHL Ligand-Linker Conjugates 1 hydrochloride;(S,R,S)-AHPC-PEG3-NH2 hydrochloride（E3 ligase Ligand-Linker Conjugates 5）;(S,R,S)-AHPC-PEG₃-NH₂ hydrochloride;(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2R,4S)-1-((R)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride;(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
CBNumber: CB53386472
Molecular Formula: C30H46ClN5O7S
Formula Weight: 656.24
MOL File: 2097971-11-2.mol

More

Less

E3 ligase Ligand-Linker Conjugates 5 Property

storage temp.: 2-8°C
form: powder or crystals
color: Light yellow to brown

More

Less

Safety

HS Code: 2934100090

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 901511
Product name: (S,R,S)-AHPC-PEG3-NH2 hydrochloride
Purity: ≥95%
Packaging: 50mg
Price: $840
Updated: 2025/07/31

Iris Biotech GmbH

Product number: PTC1330
Product name: (S,R,S)-AHPC-PEG3-NH2 hydrochloride
Packaging: 50mg
Price: $499.5
Updated: 2021/12/16

DC Chemicals

Product number: 027599
Product name: (S,R,S)-AHPC-PEG3-NH2hydrochloride（E3ligaseLigand-LinkerConjugates5）
Packaging: 001
Price: $500
Updated: 2021/12/16

CSNpharm

Product number: CSN23963
Product name: VHL032-keto-PEG3-C2-amine HCl
Packaging: 25mg
Price: $149
Updated: 2021/12/16

CSNpharm

Product number: CSN23963
Product name: VHL032-keto-PEG3-C2-amine HCl
Packaging: 100mg
Price: $326
Updated: 2021/12/16

More

Less

E3 ligase Ligand-Linker Conjugates 5 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG₃-NH₂ (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reactivity: carboxyl reactive
reagent type: ligand-linker conjugate

IC 50

VHL

E3 ligase Ligand-Linker Conjugates 5 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

E3 ligase Ligand-Linker Conjugates 5 Suppliers

CHINA 36 United Kingdom 1 United States 2 Global 39

ChemShuttle, Inc.

Tel: 0510-83588313-811 18800520310
Email: sales@chemshuttle.com
Country: China
ProdList: 2999
Advantage: 62

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
Advantage: 58

Henan Alfachem Co.,Ltd.

Tel: 0371-55051623 18137891487
Fax: QQ：2853979817
Email: 2853979817@qq.com
Country: China
ProdList: 9999
Advantage: 58

SuZhou Medinoah Co.,LTD.

Tel: 0512-69561983 13914027025
Fax: 0512-69561982
Email: zhang_q@medinoah.com
Country: China
ProdList: 3811
Advantage: 58

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
Country: China
ProdList: 1615
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel: +8615838112936
Email: alfa10@alfachem.cn
Country: China
ProdList: 12921
Advantage: 58

Shanghai UCHEM Inc.

Tel: +862156762820 +86-13564624040
Email: sales@myuchem.com
Country: China
ProdList: 8460
Advantage: 58

Shaanxi borno biotechnology co., LTD

Tel: +86-13759708231
Email: asherw9@hotmail.com
Country: China
ProdList: 2373
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18921922613
Email: hywu@aikonchem.com
Country: China
ProdList: 10709
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054;
Email: trendseenbio@gmail.com
Country: China
ProdList: 9069
Advantage: 58

Shanghai Easy CDMO Co.,Ltd

Tel: 021-61734564 13854185395;
Email: info@easycdmo.com
Country: China
ProdList: 10024
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Abosyn

Tel: 0512-69561983 13914027025
Email: he_qf@medinoah.com
Country: China
ProdList: 3001
Advantage: 58

Jilin Chinese Academy of Sciences-yanshen Technology

Tel: 18143011203
Email: ET-market@chemextension.com
Country: China
ProdList: 32035
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Enzo Biochem Inc

Tel: Enzo Biochem Inc. 13797054060
Email: Enzoname@qq.com
Country: China
ProdList: 6174
Advantage: 58

Henan Mengtai Pharmaceutical Technology Co., Ltd

Tel: 176345344 7 17634854698
Email: 1959525201@qq.com
Country: China
ProdList: 10000
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 14580
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Shanxi Tihondan Pharmaceutical Technology Co., Ltd

Tel: +8618235132063
Email: sales@tihondan.com
Country: China
ProdList: 3767
Advantage: 58

Xian confluore Biological Technology Co., Ltd.

Tel: +86-15680926068
Email: 1924344760@confluore.cn
Country: China
ProdList: 2997
Advantage: 58

Guangzhou Xinghe Biotechnology Co., Ltd.

Tel: 15889822182
Country: CHINA
ProdList: 160
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6482
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

More

Less

View Lastest Price from E3 ligase Ligand-Linker Conjugates 5 manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (S,R,S)-AHPC-PEG3-NH2 hydrochloride 2097971-11-2
Price: US $0.00/mg
Min. Order: 250mg
Purity: >98.00%
Supply Ability: 250mg
Release date: 2024-04-01

2097971-11-2, E3 ligase Ligand-Linker Conjugates 5Related Search:

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

E3 ligase Ligand-Linker Conjugates 5

VH032-PEG3-NH2 hydrochloride

VHL Ligand-Linker Conjugates 1 hydrochloride

(S,R,S)-AHPC-PEG3-NH2 hydrochloride >=95%

(S,R,S)-AHPC-PEG3-NH2 hydrochloride（E3 ligase Ligand-Linker Conjugates 5）

(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

(2R,4S)-1-((R)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

2097971-11-2