E3 ligase Ligand-Linker Conjugates 5

Product Name: E3 ligase Ligand-Linker Conjugates 5
CAS No.: 2097971-11-2
Chemical Name: E3 ligase Ligand-Linker Conjugates 5
Synonyms: VH032-PEG3-NH2 hydrochloride;(S,R,S)-AHPC-PEG3-NH2 hydrochloride;E3 ligase Ligand-Linker Conjugates 5;(S,R,S)-AHPC-PEG3-NH2 hydrochloride >=95%;VHL Ligand-Linker Conjugates 1 hydrochloride;(S,R,S)-AHPC-PEG3-NH2 hydrochloride（E3 ligase Ligand-Linker Conjugates 5）;(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2R,4S)-1-((R)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride;(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride;(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
CBNumber: CB53386472
Molecular Formula: C30H46ClN5O7S
Formula Weight: 656.24
MOL File: 2097971-11-2.mol

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E3 ligase Ligand-Linker Conjugates 5 Property

storage temp.: 2-8°C
form: powder or crystals
color: Light yellow to brown

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Safety

HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 901511
Product name: (S,R,S)-AHPC-PEG3-NH2 hydrochloride
Purity: ≥95%
Packaging: 50mg
Price: $326
Updated: 2024/03/01

Iris Biotech GmbH

Product number: PTC1330
Product name: (S,R,S)-AHPC-PEG3-NH2 hydrochloride
Packaging: 50mg
Price: $499.5
Updated: 2021/12/16

DC Chemicals

Product number: 027599
Product name: (S,R,S)-AHPC-PEG3-NH2hydrochloride（E3ligaseLigand-LinkerConjugates5）
Packaging: 001
Price: $500
Updated: 2021/12/16

DC Chemicals

Product number: 027599
Product name: (S,R,S)-AHPC-PEG3-NH2hydrochloride（E3ligaseLigand-LinkerConjugates5）
Packaging: 002
Price: $850
Updated: 2021/12/16

DC Chemicals

Product number: 027599
Product name: (S,R,S)-AHPC-PEG3-NH2hydrochloride（E3ligaseLigand-LinkerConjugates5）
Packaging: 003
Price: $1700
Updated: 2021/12/16

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E3 ligase Ligand-Linker Conjugates 5 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG₃-NH₂ (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reactivity: carboxyl reactive
reagent type: ligand-linker conjugate

E3 ligase Ligand-Linker Conjugates 5 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from E3 ligase Ligand-Linker Conjugates 5 manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (S,R,S)-AHPC-PEG3-NH2 hydrochloride 2097971-11-2
Price: US $0.00/mg
Min. Order: 250mg
Purity: >98.00%
Supply Ability: 250mg
Release date: 2024-04-01

2097971-11-2, E3 ligase Ligand-Linker Conjugates 5Related Search:

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

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2097971-11-2