JT010

ChemicalBook > CAS DataBase List > JT010

Product Name: JT010
CAS No.: 917562-33-5
Chemical Name: JT010
Synonyms: JT010;JT010, 10 mM in DMSO;2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide;2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)acetamide;Acetamide, 2-chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)-;2-Chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)acetamide , JT010;JT010,JT-010,TRP Channel,Transient receptor potential channels,inhibit,Inhibitor,JT 010
CBNumber: CB53386492
Molecular Formula: C16H19ClN2O3S
Formula Weight: 354.85
MOL File: 917562-33-5.mol

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JT010 Property

Boiling point:: 487.4±55.0 °C(Predicted)
Density: 1.265±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: powder
pka: 2.59±0.10(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1672
Product name: JT010
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $105
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1672
Product name: JT010
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $424
Updated: 2023/06/20

Cayman Chemical

Product number: 29732
Product name: JT010
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 29732
Product name: JT010
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 29732
Product name: JT010
Packaging: 10mg
Price: $166
Updated: 2024/03/01

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JT010 Chemical Properties,Usage,Production

Description

JT010 is a transient receptor potential ankyrin 1 (TRPA1) agonist (EC₅₀ = 0.65 nM in a calcium influx assay). It is selective for TRPA1 over TRP vanilloid 1 (TRPV1), TRPV3, TRPV4, TRP canonical channel 5 (TRPC5), TRP melastatin 2 (TRPM2), and TRPM8 channels at 1 μM.

Uses

JT010 is a potent and selective TRPA1 channel activator (EC50 = 65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).

Biochem/physiol Actions

JT010 is a non-cytotoxic and highly stable (>90% remains after 2 h in 1 mM DTT or 2-mercaptoethanol) chloroacetamido warhead-carrying thiazole derivative that acts as a potent and TRPA1-selective channel activator via covalent modification of TRPA1 active site Cys621. JT0101 stimulates calcium influx in TRPA1-transfected HEK293 cells in a dose-dependent manner (EC50?= 650 pM) with excellent selectivity over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50?>1 μM).

storage

Store at +4°C

JT010 Preparation Products And Raw materials

Raw materials

Preparation Products

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917562-33-5, JT010Related Search:

JT010

2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide

Acetamide, 2-chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)-

2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)acetamide

JT010,JT-010,TRP Channel,Transient receptor potential channels,inhibit,Inhibitor,JT 010

2-Chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)acetamide , JT010

JT010, 10 mM in DMSO

917562-33-5