ChemicalBook > CAS DataBase List > Lefamulin acetate

Lefamulin acetate

Product Name: Lefamulin acetate
CAS No.: 1350636-82-6
Chemical Name: Lefamulin acetate
Synonyms: Lefamulin acetate;BC-3781 ACETATE;Lefamulin Acetat;BC-3781;BC 3781;BC3781;WSMXIQXWHPSVDE-WHAUHWDVSA-N;Lefamulin acetate (Xenleta);Lefamulin acetate, 10 mM in DMSO;Lefamulin acetate (BC-3781 acetate);WSMXIQXWHPSVDE-WHAUHWDVSA-N USP/EP/BP;Inhibitor,Lefamulin,BC 3781,BC3781,Lefamulin acetate,inhibit,BC-3781,Bacterial,Antibiotic
CBNumber: CB53399603
Molecular Formula: C30H49NO7S
Formula Weight: 567.78
MOL File: 1350636-82-6.mol

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Lefamulin acetate Property

storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);176.12(Max Conc. mM)
form: Solid
color: White to off-white
InChI: InChI=1/C28H45NO5S.C2H4O2/c1-6-26(4)14-22(34-23(32)15-35-21-8-7-18(29)13-20(21)31)27(5)16(2)9-11-28(17(3)25(26)33)12-10-19(30)24(27)28;1-2(3)4/h6,16-18,20-22,24-25,31,33H,1,7-15,29H2,2-5H3;1H3,(H,3,4)/t16-,17+,18-,20-,21-,22-,24+,25+,26-,27?,28?;/s3
InChIKey: WSMXIQXWHPSVDE-IHBHSJRLNA-N
SMILES: C(=O)(O)C.C[C@H]1[C@@H]([C@](C[C@@H](OC(=O)CS[C@@H]2CC[C@@H](N)C[C@H]2O)C2([C@H](C)CCC31CCC(=O)[C@]32[H])C)(C)C=C)O |&1:5,6,7,9,15,18,21,24,33,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0012946
Product name: Lefamulin(acetate)
Purity: 98.02%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0012946
Product name: Lefamulin(acetate)
Purity: 98.02%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0012946
Product name: Lefamulin(acetate)
Purity: 98.02%
Packaging: 50mg
Price: $1100
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573027
Product name: Lefamulin acetate
Purity: >98%
Packaging: 50mg
Price: $1356.6
Updated: 2021/12/16

ChemScene

Product number: CS-0012946
Product name: Lefamulin(acetate)
Purity: 98.02%
Packaging: 100mg
Price: $1800
Updated: 2021/12/16

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Lefamulin acetate Chemical Properties,Usage,Production

Chemical Properties

Lefamulin acetate is a white to off-white solid. It is a stable compound (requiring no special storage conditions) which is highly soluble in water and 0.9% sodium chloride solution (>300mg/ml). The hydration level of lefamulin acetate at ambient conditions is typically below 1% w/w.

Uses

Lefamulin (BC-3781) acetate is an orally active antibiotic. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin acetate has anti-inflammatory activity. Lefamulin acetate can be used in the research of bacterial infections, such as bacterial pneumonia.

Definition

Lefamulin acetate is a single stereoisomer semi-synthetically derived from pleuromutilin, a homochiral, natural fermentation product of known absolute stereochemistry. Lefamulin acetate is a diastereomer with R-configuration at carbons of the cyclohexane moiety. The absolute configuration of the active substance has been confirmed by single-crystal structure determination.

Antimicrobial activity

Lefamulin acetate has activity against Gram-positive bacteria including MRSA, and atypical bacteria, especially those causing CAPB (i.e. Streptococcus pneumonia, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella pneumophila, Chlamydophila pneumoniae). It also has activity against Gram-negative organisms.

in vivo

Lefamulin (10-140 mg/kg, s.c.) acetate shows anti-inflammatory effect on LPS-induced lung neutrophilia mouse model^[4].
Lefamulin (1.25-160 mg/kg, s.c.) acetate shows antibacterial effect in S. pneumoniae or S. aureus challenged lung infection mice^[5].

Animal Model:	LPS-induced lung neutrophilia mouse model^[4]
Dosage:	10-140 mg/kg
Administration:	Subcutaneous injection (s.c.)
Result:	Reduced BALF neutrophil cell counts. Reduced pro-inflammatory cytokine (TNF-α, IL-6, IL-1β, and GM-CSF), chemokine (CXCL-1, CXCL-2, and CCL-2) and MMP-9 levels in mouse lung tissue.

Lefamulin acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Lefamulin acetate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Lefamulin acetate 1350636-82-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-19

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Lefamulin Acetat. 1350636-82-6
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2025-01-14

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Lefamulin Acetat 1350636-82-6
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-07-24

1350636-82-6, Lefamulin acetateRelated Search:

Fludrocortisone Chlorhexidine Diacetate

WSMXIQXWHPSVDE-WHAUHWDVSA-N

BC-3781;BC 3781;BC3781

Lefamulin acetate

BC-3781 ACETATE

Lefamulin acetate (BC-3781 acetate)

WSMXIQXWHPSVDE-WHAUHWDVSA-N USP/EP/BP

Inhibitor,Lefamulin,BC 3781,BC3781,Lefamulin acetate,inhibit,BC-3781,Bacterial,Antibiotic

Lefamulin acetate (Xenleta)

Lefamulin Acetat

(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-amino-2-hydroxycyclohexyl)thio)acetate acetate

Lefamulin acetate, 10 mM in DMSO

1350636-82-6