ChemicalBook > CAS DataBase List > 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE

4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE

Product Name: 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE
CAS No.: 838-88-0
Chemical Name: 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE
Synonyms: mbot;me-mda;Kayahard MDT;4.4'-DiaMino-3;Methylene-bis(2-Methylani;4,4’-methylenedi-o-toluidin;4,4 -Methylendi-o-toluidine;4,4'-methylenedi-o-toluidine;4,4'-METHYLENEBIS-O-TOLUIDINE;4,4'-METHYLENE-DI(O-TOLUIDINE)
CBNumber: CB5342200
Molecular Formula: C15H18N2
Formula Weight: 226.32
MOL File: 838-88-0.mol

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4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE Property

Melting point:: 155-157 °C
Boiling point:: 357.94°C (rough estimate)
Density: 0.9543 (rough estimate)
vapor pressure: 1.8hPa at 205.5℃
refractive index: 1.5000 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
Water Solubility: Insoluble in water
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 5.18±0.25(Predicted)
color: White to Light yellow to Light orange
BRN: 398069
InChIKey: WECDUOXQLAIPQW-UHFFFAOYSA-N
CAS DataBase Reference: 838-88-0(CAS DataBase Reference)
IARC: 2B (Vol. 4, Sup 7) 1987
EPA Substance Registry System: 4,4'-Methylenebis(2-methylaniline) (838-88-0)

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Safety

Hazard Codes: T,N
Risk Statements: 45-22-43-50/53
Safety Statements: 53-45-60-61
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
RTECS: BY5300000
F: 10-23
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29215900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H350May cause cancer

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 46106
Product name: 4,4′-Methylene-bis(2-methylaniline)
Purity: analytical standard
Packaging: 100mg
Price: $77.4
Updated: 2025/07/31

TCI Chemical

Product number: D2046
Product name: 4,4'-Diamino-3,3'-dimethyldiphenylmethane
Purity: >97.0%(T)
Packaging: 25g
Price: $329
Updated: 2025/07/31

TRC

Product number: M227470
Product name: 4,4''-Methylenedi-o-toluidine
Packaging: 10g
Price: $105
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD62628
Product name: 4,4'-Diamino-3,3'-dimethyldiphenylmethane
Packaging: 100g
Price: $442
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0011232
Product name: 4,4'-DIAMINO-3,3-DIMETHYLDIPHENYLMETHANE
Purity: 95.00%
Packaging: 25G
Price: $1154.84
Updated: 2021/12/16

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4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE Chemical Properties,Usage,Production

Chemical Properties

White powder. Soluble in ethanol and hot water.

Uses

4,4′-Methylene-bis(2-methylaniline) has been used as a reference standard for the determination of 4,4′-methylene-bis(2-methylaniline) in plastic multilayer food packaging materials by liquid chromatography (LC)-Orbitrap-full scan-high resolution mass spectrometry (HRMS).
It may be used as a reference standard for the analysis of 4,4′-methylene-bis(2-methylaniline) in dyes, cosmetics, finger paints and inks for pens and tattoos by LC-MS.

Uses

4,4'-Diamino-3,3'-dimethyldiphenylmethane can be used for preparation polyimide and epoxy resin material.

Definition

ChEBI: 4,4'-Methylene bis(2-methylaniline) is a diarylmethane.

General Description

4,4′-Methylene-bis(2-methylaniline) belongs to the primary aromatic amines (PAAs) family of compounds which are toxic in nature and are probable human carcinogens.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion. An eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

50-00-0

95-53-4

838-88-0

(1) o-toluidine, water and 37% hydrochloric acid were added into the reactor in the ratio of o-toluidine to hydrochloric acid at the molar ratio of 1:1.2 and the weight ratio of o-toluidine to water at the ratio of 1:4, and the reaction was stirred for 30 minutes; (2) the 37% formaldehyde solution was diluted to 10%; (3) the reaction solution from step (1) and the diluted formaldehyde solution from step (2) were transported via advective pumps to each of the microreactor's two inlets, controlling the molar ratio of o-toluidine to formaldehyde to be 3:1; (4) in the microreactor, the two raw materials were contacted, mixed and reacted, the reaction temperature was controlled at 40 °C, the liquid-time air velocity was 3000 h-1, and the reacted solution flowed out from the reactor outlet; (5) the reaction solution was cooled down to room temperature, and the aqueous sodium hydroxide was added dropwise to adjust pH to about 9, and a large amount of white precipitate precipitated, which was filtered, drying to obtain 3,3'-dimethyl-4,4'-diaminodiphenylmethane (MDT) crude product; (6) the crude MDT was recrystallized by ethanol, filtered and dried to obtain the pure MDT with a molar yield of 86% and a purity of 99%.

References

[1] Patent: CN106986777, 2017, A. Location in patent: Paragraph 0043-0055; 0057; 0059; 0061; 0063; 0065
[2] Catalysis Communications, 2014, vol. 45, p. 69 - 73
[3] Journal of the American Chemical Society, 1935, vol. 57, p. 887,889
[4] Journal of the American Chemical Society, 1934, vol. 57, p. 1944
[5] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982, vol. 21, # 8, p. 721 - 723

4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE Suppliers

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View Lastest Price from 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4,4'-Methylene di-o-toluidine 838-88-0
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Career Henan Chemica Co

Product: 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE 838-88-0
Price: US $1.00/g
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20tons
Release date: 2020-10-28

Nanjing jinheyou Trading Co., Ltd.

Product: 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE 838-88-0
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 20kg/month
Release date: 2019-11-05

838-88-0, 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANERelated Search:

4,4'-METHYLENEBIS(2-ISOPROPYL-6-METHYLANILINE) CARBOL FUCHSIN MBAA 4,4'-METHYLENEBIS(2,6-DIISOPROPYLANILINE) Basic Violet 2 4,4'-Diamino-3,3'-dimethyl diphenyl cyclohexane 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE 4,4'-Methylenebis(2,6-diethylaniline) 4,4'-Methylenebis(2,6-dimethylaniline) 4,4'-Methylenebis(2-ethylbenzenamine) Bis(4-amino-2-chloro-3,5-diethylphenyl)methane 4,4'-DIMETHYLBIPHENYL O-Tolidine 4,4'-Methylenedianiline 3,3'-Dimethylbiphenyl 3,4'-DIAMINODIPHENYLMETHANE Diphenylmethane AURAMINE G

4-[(4-aminophenyl)methyl]-2-methylaniline

4,4’-methylenebis(2-methyl-anilin

4,4’-methylenebis(2-methyl-benzenamin

4,4’-methylenebis(2-methylbenzenamine)

4,4’-methylenebis[2-methyl-benzenamin

4,4’-methylenedi-o-toluidin

bis(4-amino-3-methylphenyl)-methan

bis(4-amino-3-methylphenyl)methane

4,4''-DIAMINO-3,3-DIMETHYLDIPHENYLMETHANE, 95+%

4,4 -Methylendi-o-toluidine

4,4μ-Diamino-3,3μ-dimethyldiphenylmethane, 4,4μ-Methylene-di(o-toluidine)

4-(4-Amino-3-methylbenzyl)-2-methylaniline

Kayahard MDT

[4-(4-amino-3-methyl-benzyl)-2-methyl-phenyl]amine

4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline

4-[(4-azanyl-3-methyl-phenyl)methyl]-2-methyl-aniline

3,3'-Dimethyl-4,4'-diaminodiphenylmethane 1g [838-88-0]

Methylene-bis(2-Methylani

4.4'-DiaMino-3

3,3′-Dimethyl-4,4′-diaminodiphenylmethane Solution, 100ppm

3,3'-diMethyl-4,4'-diaMino-diphenyl Methan

bis-4-amino-3-methylfenylmethan

mbot

me-mda

4,4'-METHYLENE-DI(O-TOLUIDINE)

4,4'-METHYLENEBIS-O-TOLUIDINE

4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE

3,3'-DIMETHYL-4,4'-DIAMINODIPHENYLMETHANE

4-(4-amino-3-methylbenzyl)-2-methylbenzenamine

3,3'-Dimethyl-4,4'-diaminobiphenylmethane

4,4-DIAMINO-3,3-DIMETHYLDIPHENYL- METHAN

4,4-METHYLENE-BIS(2-METHYLANILINE),STAND ARD FOR GC

2,2'-Dimethyl-4,4'-methylenedianiline

4,4'-Methylenebis(2-methylbenzeneamine)

Bis(3-methyl-4-aminophenyl) methane

3,3'-Dimethyl-4,4'-diaminodiphenylmethane@10 μg/mL in Ethyl acetate

3,3'-Dimethyl-4,4'-diaminodiphenylmethane@100 μg/mL in AcCN

3,3'-Dimethyl-4,4'-diaminodiphenylmethane@1000 μg/mL in AcCN

4,4'-Diamino-3,3'-dimethyldiphenylmethane&gt

Benzenamine, 4,4'-methylenebis[2-methyl-

4,4'-Diamino-3,3'-dimethyldiphenylmethane Solution in Methanol, 100μg/mL

4,4'-Methylenbis(2-methyl)-benzolamin

4,4'-Methylene-bis(2-methylaniline)

3,3'-diMethyl-4,4'-diaMino-diphenyl Methane

3,3-Dimethyl-4,4-diaminodiphenylmethane in acetonitrile

3,3-Dimethyl-4,4-diaminodiphenylmethane in isooctane

4,4'-Diamino-3,3'-dimethyldiphenylmethane 100 μg/ml Acetonitrile

4.4‘-Diamino-3.3‘-dimethyldiphenyl methane 100ug/mL

C12194800 4.4’-Diamino-3.3’-dimethyldiphenyl

4,4'-methylenedi-o-toluidine

4,4'-(1-Methylethylidene)diphenol

4,4′-Methylene-bis(2-methylaniline), CAS 838-88-0

4,4′-Methylene-bis(2-methylaniline)

4,4'-Diamino-3,3'-dimethyldiphenyl methane 100 μg/mL in Acetonitrile

838-88-0

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