2-CHLORO-3,6-DIFLUOROBENZALDEHYDE
Uses- Product Name
- 2-CHLORO-3,6-DIFLUOROBENZALDEHYDE
- CAS No.
- 261762-39-4
- Chemical Name
- 2-CHLORO-3,6-DIFLUOROBENZALDEHYDE
- Synonyms
- TIMTEC-BB SBB003776;2-CHLORO-3,6-DIFLUOROBENZALDEHYDE;Benzaldehyde, 2-chloro-3,6-difluoro-;2-Chloro-3,6-difluorobenzaldehyde 96%;2-Chloro-3,6-difluorobenzaldehyde, 97.5%;a-Bromo-3',6'-bis(trifluoromethyl)acetophenone;2-CHLORO-3,6-DIFLUOROBENZALDEHYDE ISO 9001：2015 REACH
- CBNumber
- CB5349300
- Molecular Formula
- C7H3ClF2O
- Formula Weight
- 176.55
- MOL File
- 261762-39-4.mol
2-CHLORO-3,6-DIFLUOROBENZALDEHYDE Property
- Melting point:
- 46-50 °C (lit.)
- Boiling point:
- 206.4±35.0℃ (760 Torr)
- Density
- 1.453±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
- Sensitive
- Air Sensitive
- CAS DataBase Reference
- 261762-39-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 526428
- Product name
- 2-Chloro-3,6-difluorobenzaldehyde
- Purity
- 96%
- Packaging
- 5g
- Price
- $115
- Updated
- 2023/06/20
- Product number
- T775553
- Product name
- 2-Chloro-3,6-difluorobenzaldehyde
- Packaging
- 2.5g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- X3101
- Product name
- 2-Chloro-3,6-difluorobenzaldehyde
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- JK424140
- Product name
- 2-Chloro-3,6-difluorobenzaldehyde
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0019080
- Product name
- 2-CHLORO-3,6-DIFLUOROBENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $594.96
- Updated
- 2021/12/16
2-CHLORO-3,6-DIFLUOROBENZALDEHYDE Chemical Properties,Usage,Production
Uses
2-Chloro-3,6-difluorobenzaldehyde is an aldehyde derivative that can be used as a pharmaceutical intermediate to prepare the downstream product 2-chloro-3,6-difluorobenzonitrile.
General Description
2-Chloro-3,6-difluorobenzaldehyde is a trisubstituted benzaldehyde. Fourier-transform, laser Raman (in the range of 3500-50cm-1) and infrared (in the range of 4000-400cm-1) spectral analyses of 2-chloro-3,6-difluorobenzaldehyde have been reported.
Synthesis
2367-91-1
68-12-2
261762-39-4
Example 152A Synthesis of 2-chloro-3,6-difluorobenzaldehyde: 2-chloro-1,4-difluorobenzene (1.78 g, 12.0 mmol) was dissolved in tetrahydrofuran (50 mL) and the solution was cooled to -78°C. Lithium diisopropylammonium (1.8 M in tetrahydrofuran, 7.3 mL, 13.2 mmol) was added slowly with stirring. The reaction temperature was maintained at -78 °C and stirring was continued for 30 min. Subsequently, N,N-dimethylformamide (1.05 g, 14.4 mmol) was added and stirring was continued at the same temperature for 15 min. After the reaction was completed, acetic acid (3 mL) and water (100 mL) were added and the mixture was gradually warmed up to room temperature. Extraction was carried out with ethyl acetate and the organic phases were combined and washed sequentially with 1 M hydrochloric acid solution and saturated saline. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford the target product 2-chloro-3,6-difluorobenzaldehyde (1.51 g, 71% yield). The product was analyzed by GC-MS (Method 1G): retention time Rt = 3.25 min, mass spectrum (ESI positive ion mode): m/z = 177 [M + H]+.
References
[1] Patent: WO2015/67549, 2015, A1. Location in patent: Page/Page column 143
[2] Patent: US2015/126449, 2015, A1. Location in patent: Paragraph 0803 - 0806
2-CHLORO-3,6-DIFLUOROBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-3,6-DIFLUOROBENZALDEHYDE manufacturers
- Product
- 2-CHLORO-3,6-DIFLUOROBENZALDEHYDE 261762-39-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2020-01-08